1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Ceftazidime pentahydrate

Ceftazidime pentahydrate (Synonyms: GR20263 pentahydrate)

Cat. No.: HY-B0593A Purity: 98.76%
Handling Instructions

Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.

For research use only. We do not sell to patients.

Ceftazidime pentahydrate Chemical Structure

Ceftazidime pentahydrate Chemical Structure

CAS No. : 78439-06-2

Size Price Stock Quantity
500 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Ceftazidime pentahydrate:

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  • Biological Activity

  • Purity & Documentation

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Description

Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases[1].

In Vitro

Ceftazidime (0-8 µg/mL approximately, 24 h) pentahydrate displays antibacterial and anti-biofilm activities against P. aeruginosa strains[2].
Ceftazidime (0-40 µg/mL approximately, 18-20 h) pentahydrate has inhibitory activities against S. maltophilia isolates[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: P. aeruginosa strains (PAO1, PA1, PA2)
Concentration: 0-8 µg/mL approximately
Incubation Time: 24 h
Result: Displayed antibacterial and anti-biofilm activities with MIC values of 2-4 µg/mL.
In Vivo

Ceftazidime (2 h infusion of injection, 2 000 mg, every 8 h for 24 h) pentahydrate moderately reduces bacterial density in a murine thigh infection model[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine thigh infection model[4]
Dosage: 2000 mg
Administration: 2 h infusion of injection, every 8 h for 24 h.
Result: Reduced bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain.
Clinical Trial
Molecular Weight

636.65

Formula

C22H32N6O12S2

CAS No.
SMILES

O=C1[[email protected]@H](NC(/C(C2=CSC(N)=N2)=N\OC(C)(C(O)=O)C)=O)[[email protected]@]3([H])SCC(C[N+]4=CC=CC=C4)=C(C([O-])=O)N13.[5H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (157.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5707 mL 7.8536 mL 15.7072 mL
5 mM 0.3141 mL 1.5707 mL 3.1414 mL
10 mM 0.1571 mL 0.7854 mL 1.5707 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.93 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.93 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Ceftazidime pentahydrate
Cat. No.:
HY-B0593A
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