1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. OP-3633

OP-3633 

Cat. No.: HY-125839
Handling Instructions

OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism.

For research use only. We do not sell to patients.

OP-3633 Chemical Structure

OP-3633 Chemical Structure

CAS No. : 2102494-14-2

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Description

OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].

IC50 & Target

IC50: 29 nM (GR)[1]

In Vitro

OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1].
OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].

Molecular Weight

445.64

Formula

C₃₀H₃₉NO₂

CAS No.

2102494-14-2

SMILES

O=C1CC[[email protected]]2(C)[[email protected]@]3([H])[[email protected]@H](C4=CC=C(N(C)C)C=C4)C[[email protected]]5(C)[[email protected]@](C#CC)(O)CC[[email protected]@]5([H])[[email protected]]3([H])CCC2=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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