1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Dazucorilant

Dazucorilant (Synonyms: CORT113176)

Cat. No.: HY-132811
Handling Instructions

Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value <1 nM in vitro. Dazucorilant can be used for the research of neurological disorders.

For research use only. We do not sell to patients.

Dazucorilant Chemical Structure

Dazucorilant Chemical Structure

CAS No. : 1496508-34-9

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Description

Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value <1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[1][2].

IC50 & Target

GR[1]

In Vitro

In HepG2 human cells or in human hepatocytes, Dazucorilant acts as full antagonist since it is able to prevent the dexamethasone-induced increase in TAT activity and to induce non-measurable agonist activity in the absence of dexamethasone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dazucorilant (30 mg/kg/day; s.c.) makes mice show reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity[1].
Dazucorilant (5, 10 or 20 mg/kg; i.p.) reverses hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restores the hippocampal levels of synaptic markers, reestablishes basal plasma levels of glucocorticoids and improves cognitive function at a dose of 10 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wobbler mice (five-month-old)[1]
Dosage: 30 mg/kg/day
Administration: S.c.
Result: Wobbler mice showed reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity.
Animal Model: Adult SD male rats[2]
Dosage: 5, 10 or 20 mg/kg
Administration: I.p.
Result: Reversed hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restored the hippocampal levels of synaptic markers, reestablished basal plasma levels of glucocorticoids and improved cognitive function at a dose of 10 mg/kg.
Clinical Trial
Molecular Weight

582.57

Formula

C₂₉H₂₂F₄N₄O₃S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Dazucorilant
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