1496508-34-9
Chemical Structure
Dazucorilant
Synonym(s): CORT113176
- CAS No.: 1496508-34-9
- Formula:C29H22F4N4O3S
- Molecular Weight:582.57
IUPAC Name: (R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl)(pyridin-2-yl)methanone
InChIKey: VXOBXKQLNWYQPQ-NDEPHWFRSA-N
SMILES: O=C(C1=CC=CC=N1)[C@@]23C(CCN(C3)S(=O)(C4=CC=C(C=C4)C(F)(F)F)=O)=CC5=C(C=NN5C6=CC=C(C=C6)F)C2
Biological Activity: Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[1][2].
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Dazucorilant | 98.91% | Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders. | ||||||||||||||||||||
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- [1]. Meyer M, et al. The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord. Neuroscience. 2018;384:384-396. [Content Brief]
- [2]. Pineau F, et al. New selective glucocorticoid receptor modulators reverse amyloid-β peptide-induced hippocampus toxicity. Neurobiol Aging. 2016;45:109-122. [Content Brief]
Keywords
