CAMKIV/CAMK4 Protein, Mouse (sf9)

CAMKIV/CAMK4 protein is a calcium/calmodulin-dependent protein kinase that functions in the CaMKK-CaMK4 signaling cascade triggered by calcium, regulating the activity of various transcription activators through phosphorylation. These transcription activators, including CREB1, MEF2D, JUN, and RORA, play crucial roles in immune response, inflammation, and memory consolidation. In the thymus, CAMKIV/CAMK4 controls the selection threshold of CD4(+)/CD8(+) double positive thymocytes during T-cell development. In CD4 memory T-cells, it is necessary for connecting T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG, and IL4 by regulating CREB and MEF2. Additionally, CAMKIV/CAMK4 is involved in the differentiation and survival of osteoclasts and dendritic cells (DCs). It promotes DCs survival by linking TLR4 signaling and regulating the temporal expression of BCL2. In hippocampal neuron nuclei, CAMKIV/CAMK4 phosphorylates the transcription activator CREB1 at 'Ser-133', contributing to memory consolidation and long-term potentiation (LTP) in the hippocampus. It can activate MAP kinases, such as MAPK1/ERK2, MAPK8/JNK1, and MAPK14/p38, and stimulate transcription through the phosphorylation of ELK1 and ATF2. Additionally, CAMKIV/CAMK4 can phosphorylate CREBBP, PRM2, MEF2A, and STMN1/OP18 in vitro, suggesting its potential involvement in spermatogenesis.