Camk4 - calcium/calmodulin-dependent protein kinase IV Gene

Also Known as CaMKIV; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12326

Summary

Predicted to enable calcium-dependent protein serine/threonine kinase activity; Calmodulin binding activity; and calmodulin-dependent protein kinase activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including neuron-neuron synaptic transmission; nucleocytoplasmic transport; and positive regulation of protein export from nucleus. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and nucleus. Is expressed in several structures, including alimentary system; brain; eye; hemolymphoid system gland; and reproductive system. Orthologous to human CAMK4 (calcium/Calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Apr 2022]

Camk4 Products (1)

mRNA	Protein	Name
NM_009793.3	NP_033923.2	calcium/calmodulin-dependent protein kinase type IV

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15719015	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within neuron-neuron synaptic transmission	IMP IMP: Inferred from mutant phenotype	10964952	MGI
acts upstream of or within nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	12130539	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10964952	MGI
acts upstream of or within positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	11081517	MGI
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	10964952	MGI
involved in postsynapse to nucleus signaling pathway	IEP IEP: Inferred from expression pattern	10964952	MGI
involved in postsynapse to nucleus signaling pathway	IMP IMP: Inferred from mutant phenotype	10964952	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	10964952	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IEP IEP: Inferred from expression pattern	10964952	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	10964952	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11081517	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	10964952	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12130539	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	10964952	MGI
is active in GABA-ergic synapse	IEP IEP: Inferred from expression pattern	10964952	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	10964952	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15719015	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10964952	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	10964952	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10964952	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15719015	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calcium/calmodulin-dependent protein kinase type IV	CAM kinase-GR Ca2+/calmodulin-dependent protein kinase type IV/Gr caMK IV

Recombinant Camk4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75457	CAMKIV/CAMK4 Protein, Mouse (sf9)	P08414 (N-G&P, M1-Y469)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01864	CAMK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17145	Camk4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23593	Camk4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Camk4	NCBI	NCBI:814
Rattus norvegicus	Camk4	NCBI	NCBI:25050