CAMK4 - calcium/calmodulin dependent protein kinase IV Gene

Also Known as caMK; CaMKIV; CaMK IV; CaMK-GR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 814

About CAMK4

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,223,583-111,494,886 (from NCBI)

This gene has 13 transcripts (splice variants), 173 orthologues and 6 paralogues. Broad expression in brain (RPKM 7.0), lymph node (RPKM 3.7) and 21 other tissues.

Summary

The product of this gene belongs to the serine/threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

CAMK4 Products (5)

mRNA Protein Name
NM_001323374.2 NP_001310303.1 calcium/calmodulin-dependent protein kinase type IV isoform 1
NM_001323375.2 NP_001310304.1 calcium/calmodulin-dependent protein kinase type IV isoform 1
NM_001323376.2 NP_001310305.1 calcium/calmodulin-dependent protein kinase type IV isoform 2
NM_001323377.2 NP_001310306.1 calcium/calmodulin-dependent protein kinase type IV isoform 2
NM_001744.6 NP_001735.1 calcium/calmodulin-dependent protein kinase type IV isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
8107230 GOA
Biological Process GO Annotation Evidence References Source
involved in long-term memory IGI
IGI: Inferred from genetic interaction
18829949 GOA
involved in myeloid dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
17909078 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8855261 GOA
NOT involved in positive regulation of myeloid dendritic cell cytokine production IMP
IMP: Inferred from mutant phenotype
17909078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (46 - 300)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type IV

  • CAM kinase IV

CAMK4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81263 CaMKIV Antibody (YA942) WB Human
HY-P81263A CaMKIV Antibody (YA943) WB, IHC-P, ICC/IF, IP, FC Human
HY-P85421 CaMKIV Antibody (YA5113) WB Human, Mouse, Rat, Chicken, Dog, Pig
HY-P85537 CaMKIV Antibody (YA5229) WB Human

Related Diseases

Diseases Alias
Cerebral Hypoxia

  • Brain Hypoxia
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Fragile X Syndrome

  • FXS

  • Martin-Bell Syndrome

  • Fraxa Syndrome

  • Marker X Syndrome

  • X-Linked Mental Retardation And Macroorchidism

  • Fragile X Mental Retardation Syndrome

  • Fra Syndrome

  • Mental Retardation, X-Linked, Associated With Marxq28

  • X-Linked Intellectual Disability And Macroorchidism

  • Frax Syndrome

  • Symptomatic Form Of Fragile X Syndrome In Female Carriers

  • Fragile-X Syndrome

  • Fraxe Syndrome
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01864 CAMK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17145 Camk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23593 Camk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CAMK4 RGD RGD:2264
Bos taurus CAMK4 VGNC VGNC:106668
Canis familiaris CAMK4 VGNC VGNC:53157
Felis catus CAMK4 VGNC VGNC:60335
Macaca mulatta CAMK4 VGNC VGNC:70526
Mus musculus CAMK4 MGD MGI:88258
Others CAMK4 NCBI