2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. GR 87389

GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra.

For research use only. We do not sell to patients.

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GR 87389 Chemical Structure

GR 87389 Chemical Structure

CAS No. : 141663-86-7

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GR 87389 Related Antibodies

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Description

GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].

IC50 & Target[1]

NK2

 

In Vitro

GR 87389 is a non-peptide and peptide tachykinin antagonist with Ki values of 4.0, 5.2, and 14 nM for hippocampus, urinary bladder and duodenum, respectively[1].
GR 87389 (30-300 nM) antagonized GA 64349-induced smooth muscle strips contractions in human isolated detrusor, prostate and prostatic urethra[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GR 87389 Related Antibodies
Molecular Weight

900.07

Formula

C47H65N9O9
CAS No.
Sequence Shortening

{Boc}-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GR 87389 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR 87389141663-86-7GR87389GR-87389Neurokinin ReceptorNK receptorTachykinin receptorcontractilehippocampusurinary bladderduodenumInhibitorinhibitorinhibit

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