GR 87389
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra.
For research use only. We do not sell to patients.
- CAS No.: 141663-86-7
- Formula: C47H65N9O9
- Molecular Weight:900.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NK2R |
GR 87389 is a non-peptide and peptide tachykinin antagonist with Ki values of 4.0, 5.2, and 14 nM for hippocampus, urinary bladder and duodenum, respectively[1].
GR 87389 (30-300 nM) antagonized GA 64349-induced smooth muscle strips contractions in human isolated detrusor, prostate and prostatic urethra[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141663-86-7
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Molecular Weight 900.07
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Formula C47H65N9O9
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Sequence Shortening
{Boc}-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. [Content Brief]
[2]. Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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