141663-86-7
141663-86-7
Chemical Structure
GR 87389
- CAS No.: 141663-86-7
- Formula:C47H65N9O9
- Molecular Weight:900.07
InChIKey: TULKQVVKMIIQFE-DWZVVYGRSA-N
SMILES: O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](C)NC(OC(C)(C)C)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O
Biological Activity: GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
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GR 87389 | GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra. | |||||||||||||||||||||
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References
- [1]. Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. [Content Brief]
- [2]. Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5. [Content Brief]
