2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. GR 94800

GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GR 94800

GR 94800 Chemical Structure

CAS No. : 141636-65-9

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GR 94800:

GR 94800 Related Antibodies

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NK1R NK2R NK3R

  • Biological Activity

  • Purity & Documentation

  • References

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Description

GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[1][2].

In Vitro

Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GR 94800 Related Antibodies
Molecular Weight

904.06

Formula

C49H61N9O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Bz-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (110.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1061 mL 5.5306 mL 11.0612 mL
5 mM 0.2212 mL 1.1061 mL 2.2122 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1061 mL 5.5306 mL 11.0612 mL 27.6530 mL
5 mM 0.2212 mL 1.1061 mL 2.2122 mL 5.5306 mL
10 mM 0.1106 mL 0.5531 mL 1.1061 mL 2.7653 mL
15 mM 0.0737 mL 0.3687 mL 0.7374 mL 1.8435 mL
20 mM 0.0553 mL 0.2765 mL 0.5531 mL 1.3827 mL
25 mM 0.0442 mL 0.2212 mL 0.4424 mL 1.1061 mL
30 mM 0.0369 mL 0.1844 mL 0.3687 mL 0.9218 mL
40 mM 0.0277 mL 0.1383 mL 0.2765 mL 0.6913 mL
50 mM 0.0221 mL 0.1106 mL 0.2212 mL 0.5531 mL
60 mM 0.0184 mL 0.0922 mL 0.1844 mL 0.4609 mL
80 mM 0.0138 mL 0.0691 mL 0.1383 mL 0.3457 mL
100 mM 0.0111 mL 0.0553 mL 0.1106 mL 0.2765 mL
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GR 94800 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR 94800141636-65-9GR94800GR-94800Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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