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  3. Antitrypanosomal agent 1

Antitrypanosomal agent 1 

Cat. No.: HY-W052512 Purity: >95.0%
Handling Instructions

Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity.

For research use only. We do not sell to patients.

Antitrypanosomal agent 1 Chemical Structure

Antitrypanosomal agent 1 Chemical Structure

CAS No. : 75144-12-6

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10 mM * 1 mL in DMSO USD 95 In-stock
Estimated Time of Arrival: December 31
100 mg USD 95 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].

IC50 & Target

IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)[1]
EC50: 1 μM (T. brucei)[1]

In Vitro

Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20[1].

Molecular Weight

282.59

Formula

C₁₁H₁₄Cl₃NO

CAS No.

75144-12-6

SMILES

O=C(C1=CC=C(Cl)C(Cl)=C1)CCN(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Antitrypanosomal agent 1Antitrypanosomal agent1Antitrypanosomal agent-1ParasitetrypanothionereductaseT.bruceiglutathioneanti-trypanosomalInhibitorinhibitorinhibit

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Antitrypanosomal agent 1
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