Sumatriptan hydrochloride
Based on 7 publication(s) in Google Scholar
Sumatriptan hydrochloride (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan hydrochloride can be used for migraine headache research.
For research use only. We do not sell to patients.
- CAS No.: 103628-62-2
- Formula: C14H22ClN3O2S
- Molecular Weight:331.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sumatriptan hydrochloride
More- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- J Headache Pain. 2024 Oct 30;25(1):187. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
- Headache. 2026 Jun 8. [Abstract]
- Mol Pharmacol. 2023 Nov;104(5):230-238. [Abstract]
- Personalized Medicine Universe. 2019 May.
All 5-HT Receptor Isoforms
More
Biological Activity
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5-HT1D Receptor 17 nM (Ki) |
5-HT1B Receptor |
5-HT1D Receptor |
5-HT1F Receptor |
5-HT1B Receptor 27 nM (Ki) |
5-HT1A Receptor 100 nM (Ki) |
5-HT1D Receptor 7.3 nM (IC50) |
5-HT1B Receptor 9.3 nM (IC50) |
5-HT1F Receptor 17.8 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 103628-62-2
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Molecular Weight 331.86
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Formula C14H22ClN3O2S
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SMILES
O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O.Cl
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Synonyms
GR 43175 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
J Headache Pain
Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action. [Abstract]2024 Oct 30;25(1):187. PMID: 39478486 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Headache
Inhibiting astrocyte activation is effective in triptan-induced medication-overuse headache model and prolonged hyperalgesia. [Abstract]2026 Jun 8. PMID: 42260315 -
Mol Pharmacol
2023 Nov;104(5):230-238. PMID: 37567783 -
Purity & Documentation
References
[1]. S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163(1):133-6. [Content Brief]
[2]. K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43(5):776-98. [Content Brief]
[3]. Razzaque Z, et al. Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47(1):75-82. [Content Brief]
[4]. Bates EA, et al. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010 Feb;30(2):170-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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