HNSS peptide
HNSS peptide is a chimeric hybrid peptide composed of the neuroprotective peptide S14G-Humanin and the mitochondria-targeted antioxidant peptide SS31. HNSS peptide is readily cleared in vivo and can be combined with nanocarriers to improve its stability. HNSS can be delivered via the FGFR1-targeting nanocarrier FGL-NP (Cit), ameliorating mitochondrial dysfunction, Aβ deposition, tau hyperphosphorylation, and cholinergic neuronal damage, and alleviating memory deficits in Alzheimer's disease mice. HNSS peptide is applicable for Alzheimer's disease-related research.
For research use only. We do not sell to patients.
- Formula: C154H255N45O37S2
- Molecular Weight:3393.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
p-STAT3 |
In Vitro
HNSS peptide is efficiently encapsulated into NP (Cit) nanoparticles via electrostatic interactions, with high encapsulation efficiency and drug loading capacity; after encapsulation, its stability in plasma and brain homogenate is significantly enhanced, and it exhibits pH-responsive drug release characteristics, with accelerated HNSS release under acidic pH 5.0 conditions[1].
HNSS peptide (10 μM) most effectively inhibits H2O2-induced intracellular and mitochondrial ROS production in HT22 cells[1].
HNSS peptide (10 μM; 24 h) most effectively restores mitochondrial function in Aβ25-35 (HY-P0128)-treated HT22 cells by upregulating p-STAT3, MTCO1, and MnSOD, and by improving mitochondrial membrane potential, ATP levels, and cell viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT22 cells
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Concentration:25 μM Aβ25-35 (HY-P0128)
10 μM HNSS preparations -
Incubation Time:24 h
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Result:Strongly upregulated the expression of p-STAT3, MTCO1, and MnSOD.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 3393.08
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Formula C154H255N45O37S2
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SMILES
O=C([C@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)C(C)C)=O)CCC2)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CS)=O)CO)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)CCC1)=O)C)=O)CCSC)=O)=O)=O)CC4=CC=CC=C4)=O)CCCCN)=O)CC5=C(C=C(O)C=C5C)C
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Sequence
DArg-Tyr(2,6-diMe)-Lys-Phe-Gly-Gly-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-NH2
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Sequence Shortening
DArg-Tyr(2,6-diMe)-KFGGMAPRGFSCLLLLTGEIDLPVKRRA-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HNSS peptide Related Classifications
HY-P12338 Related Classifications
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