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Cat. No.: HY-176555

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Z169667518

Z169667518 is an IL-6 inhibitor. Z169667518 inhibits IL-6-induced STAT3 reporter gene signaling.

For research use only. We do not sell to patients.

CAS No.: 941127-19-1
Formula: C₂₃H₁₈N₄O
Molecular Weight:366.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Z169667518 Chemical Structure

CAS No.: 941127-19-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Z169667518 is an IL-6 inhibitor. Z169667518 inhibits IL-6-induced STAT3 reporter gene signaling^[1].

IC₅₀ & Target

^[1]

IL-6

STAT3

All Interleukin Related Isoforms :

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC50	2.7 μM	Inhibition of IL6-induced STAT3 luciferase reporter activity in HEK293T cells assessed after 5 hrs exposure by dual-luciferase reporter assay. Inhibition of IL6-induced STAT3 luciferase reporter activity in HEK293T cells assessed after 5 hrs exposure by dual-luciferase reporter assay.	40733185

In Vitro

Z169667518 (10 µM; 5 h) inhibits IL6-induced STAT3 reporter activity in HEK293T cells, producing ~84% inhibition at 10 µM and an IC₅₀ of 2.7 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 941127-19-1
Molecular Weight 366.42
Formula C₂₃H₁₈N₄O
SMILES

O=C(C1=CC=C(C=C1)C#CC2=CC=CC=C2)NCCC3=NN=C4C=CC=CN43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Joshi A, et al. Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6. Molecules. 2025 Jul 10;30(14):2919. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Z169667518

All Interleukin Related Isoforms

All STAT Isoforms