CHI3L1-IN-7
CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a Kd of 7.40 μM and an IC50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3, inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation.
For research use only. We do not sell to patients.
- CAS No.: 2248987-74-6
- Formula: C17H19N5O2S
- Molecular Weight:357.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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STAT3 |
CHI3L1-IN-7 (100 μM) binds to CHI3L1 protein with Kd = 7.40 μM[1].
CHI3L1-IN-7 inhibits the interaction of CHI3L1 and galectin-3 with IC50 = 15.4 μM in AlphaLISA assay[1].
CHI3L1-IN-7 (10-50 μM; 72 h) reduces the viability of multicellular 3D glioblastoma (GBM) spheroids and inhibits STAT3 phosphorylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:multicellular 3D glioblastoma (GBM) spheroids
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Concentration:10, 25, 50 μM
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Incubation Time:72 h
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Result:Reduced the viability of multicellular 3D glioblastoma (GBM) spheroids.
Chemical Information
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CAS No. 2248987-74-6
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Molecular Weight 357.43
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Formula C17H19N5O2S
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SMILES
CC1=C(C=NN1C2CCCC2)NC(CN3C=NC4=C(C3=O)C=CS4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHI3L1-IN-7 Related Classifications
HY-181783 Related Classifications
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