2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling
  3. Glycosidase STAT
  4. CHI3L1-IN-7

CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a Kd of 7.40 μM and an IC50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3, inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation.

For research use only. We do not sell to patients.

CHI3L1-IN-7

CHI3L1-IN-7 Chemical Structure

CAS No. : 2248987-74-6

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CHI3L1-IN-7 Related Antibodies

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Description

CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a Kd of 7.40 μM and an IC50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3, inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation[1].

IC50 & Target

STAT3

 

In Vitro

CHI3L1-IN-7 (100 μM) binds to CHI3L1 protein with Kd = 7.40 μM[1].
CHI3L1-IN-7 inhibits the interaction of CHI3L1 and galectin-3 with IC50 = 15.4 μM in AlphaLISA assay[1].
CHI3L1-IN-7 (10-50 μM; 72 h) reduces the viability of multicellular 3D glioblastoma (GBM) spheroids and inhibits STAT3 phosphorylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHI3L1-IN-7 Related Antibodies

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: multicellular 3D glioblastoma (GBM) spheroids
Concentration: 10, 25, 50 μM
Incubation Time: 72 h
Result: Reduced the viability of multicellular 3D glioblastoma (GBM) spheroids.
Molecular Weight

357.43

Formula

C17H19N5O2S
CAS No.
SMILES

CC1=C(C=NN1C2CCCC2)NC(CN3C=NC4=C(C3=O)C=CS4)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHI3L1-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHI3L1-IN-72248987-74-6GlycosidaseSTATgalectin-3STAT3CHI3L1glioblastoma spheroidsglioblastomaInhibitorinhibitorinhibit

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