2248987-74-6
2248987-74-6
Chemical Structure
CHI3L1-IN-7
- CAS No.: 2248987-74-6
- Formula:C17H19N5O2S
- Molecular Weight:357.43
InChIKey: XRYABESRJLRZOG-UHFFFAOYSA-N
SMILES: CC1=C(C=NN1C2CCCC2)NC(CN3C=NC4=C(C3=O)C=CS4)=O
Biological Activity: CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a Kd of 7.40 μM and an IC50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3, inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation[1].
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CHI3L1-IN-7 | CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a Kd of 7.40 μM and an IC50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3, inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation. | |||||||||||||||||||||
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References
Keywords
