MLS-2384 free base
MLS-2384 free base is a dual JAK/Src kinase inhibitor. MLS-2384 free base downregulates STAT3 downstream proteins c-Myc and Mcl-1. MLS-2384 free base induces Apoptosis. MLS-2384 free base exhibits anticancer activity against prostate cancer, breast cancer, skin cancer, ovarian cancer, lung cancer, and liver cancer.
For research use only. We do not sell to patients.
- CAS No.: 1067884-45-0
- Formula: C22H22BrN5O2
- Molecular Weight:468.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
STAT3 |
Mcl-1 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KCL-22 | IC50 |
0.78 μM
Compound: 21
|
Cytotoxicity against human KCL22 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human KCL22 cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 27726390] |
| SH-SY5Y | IC50 |
0.15 μM
Compound: 11
|
Inhibition of GSK3-mediated beta-casein phosphorylation in human SH-SY5Y cells in presence of MG132 by Western blot analysis
Inhibition of GSK3-mediated beta-casein phosphorylation in human SH-SY5Y cells in presence of MG132 by Western blot analysis
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[PMID: 18816110] |
| SH-SY5Y | IC50 |
13.2 μM
Compound: 11
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Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
|
[PMID: 18816110] |
Chemical Information
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CAS No. 1067884-45-0
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Molecular Weight 468.35
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Formula C22H22BrN5O2
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SMILES
O=C1NC2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCCN5CCNCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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