2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. JAK Src STAT c-Myc Bcl-2 Family Apoptosis
  4. MLS-2384 free base

MLS-2384 free base is a dual JAK/Src kinase inhibitor. MLS-2384 free base downregulates STAT3 downstream proteins c-Myc and Mcl-1. MLS-2384 free base induces Apoptosis. MLS-2384 free base exhibits anticancer activity against prostate cancer, breast cancer, skin cancer, ovarian cancer, lung cancer, and liver cancer.

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MLS-2384 free base

MLS-2384 free base Chemical Structure

CAS No. : 1067884-45-0

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MLS-2384 free base Related Antibodies

Top Publications Citing Use of Products

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STAT3 STAT5 STAT6 STAT1

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Description

MLS-2384 free base is a dual JAK/Src kinase inhibitor. MLS-2384 free base downregulates STAT3 downstream proteins c-Myc and Mcl-1. MLS-2384 free base induces Apoptosis. MLS-2384 free base exhibits anticancer activity against prostate cancer, breast cancer, skin cancer, ovarian cancer, lung cancer, and liver cancer[1].

IC50 & Target[1]

STAT3

 

Mcl-1

 

Molecular Weight

468.35

Formula

C22H22BrN5O2
CAS No.
SMILES

O=C1NC2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCCN5CCNCC5
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MLS-2384 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLS-23841067884-45-0MLS2384MLS 2384JAKSrcSTATc-MycBcl-2 FamilyApoptosisJanus kinaseMycprostate cancerbreast cancerskin cancerovarian cancerlung cancerand liver cancerInhibitorinhibitorinhibit

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