STAT3/NF-κB-IN-2
STAT3/NF-κB-IN-2 is a dual STAT3/NF-κB inhibitor that exhibits antiproliferative, antimigratory and anti-invasive activities in cancer cells. STAT3/NF-κB-IN-2 inhibits the transcriptional activities of NF-κB and STAT3, binds to the STAT3-SH2 domain, and blocks STAT3 dimerization. STAT3/NF-κB-IN-2 can be used in studies related to triple-negative breast cancer.
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- Formule: C24H20F2N2S
- Masse moléculaire:406.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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NF-κB |
STAT3 |
STAT3/NF-κB-IN-2 (compound 5b) (0-100 μM; 72 h) potently inhibits the proliferation of 4T1-Luc2, MDA-MB-231 and MC-38 cancer cells, with IC50 values of 10.4 μM, 7.22 μM and 8.35 μM, respectively[1].
STAT3/NF-κB-IN-2 (10-100 μM; 24 h) is a potent and specific dual inhibitor of NF-κB and STAT3 transcriptional activity. When applied to 4T1 cells at a subcytotoxic concentration of 10 μM, it inhibits approximately 80% of NF-κB activity and approximately 60% of STAT3 activity[1].
STAT3/NF-κB-IN-2 (10 μM; 24 h) potently inhibits the migration and invasion abilities of 4T1-Luc2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4T1-Luc2 murine breast cancer cells, MDA-MB-231 human breast cancer cells, MC-38 murine colon adenocarcinoma cells
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Concentration:0, 1, 10, 100 μM
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Incubation Time:72 h
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Result:Exhibited potent antiproliferative activity, with IC50 values of 10.4 μM in 4T1-Luc2 cells, 7.22 μM in MDA-MB-231 cells, and 8.35 μM in MC-38 cells.
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Cell Line:4T1-Luc2 murine breast cancer cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Resulted in > 91% wound persistence (8.8% healing rate) after 24 h, compared to the significant wound closure observed in untreated controls.
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Cell Line:4T1-Luc2 murine breast cancer cells
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Concentration:10 μM
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Incubation Time:24 h (pre-incubation); 5 h (invasion incubation)
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Result:Caused a marked reduction in the number of invasive 4T1-Luc2 cells compared to untreated controls.
Chemical Information
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Masse moléculaire 406.49
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Formule C24H20F2N2S
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SMILES
CC1=C(CC2=CC=CC=C2)N=C(SCC3=C(F)C=CC=C3F)N1C4=CC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT3/NF-κB-IN-2 Related Classifications
HY-184734 Related Classifications
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