MMP-2/9-IN-2
MMP-2/9-IN-2 (Compound 6k) is a MMP-2 and MMP-9 inhibitor, with IC50 values of 29.27 and 24.87 μM respectively. MMP-2/9-IN-2 exhibits good selective toxicity against multiple human hepatoma cell lines. MMP-2/9-IN-2 induces cell cycle arrest and apoptosis, significantly inhibits cell migration and invasion. MMP-2/9-IN-2 inhibits the phosphorylation of the STAT3 signaling pathway. MMP-2/9-IN-2 shows strong anti-tumor activity in a nude mouse xenograft model of HepG2 liver cancer cells.
For research use only. We do not sell to patients.
- Formula: C23H31N3O4
- Molecular Weight:413.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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MMP-2 29.27 μM (IC50) |
MMP-9 24.87 μM (IC50) |
STAT3 |
Chemical Information
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Molecular Weight 413.51
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Formula C23H31N3O4
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SMILES
O=C(NCCCN(C)C)NC1=CC(/C=C\C2=CC(OC)=CC(OC)=C2)=CC=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)