2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. MMP STAT Apoptosis
  4. MMP-2/9-IN-2

MMP-2/9-IN-2 (Compound 6k) is a MMP-2 and MMP-9 inhibitor, with IC50 values of 29.27 and 24.87 μM respectively. MMP-2/9-IN-2 exhibits good selective toxicity against multiple human hepatoma cell lines. MMP-2/9-IN-2 induces cell cycle arrest and apoptosis, significantly inhibits cell migration and invasion. MMP-2/9-IN-2 inhibits the phosphorylation of the STAT3 signaling pathway. MMP-2/9-IN-2 shows strong anti-tumor activity in a nude mouse xenograft model of HepG2 liver cancer cells.

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MMP-2/9-IN-2

MMP-2/9-IN-2 Chemical Structure

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MMP-2/9-IN-2 Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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STAT3 STAT5 STAT6 STAT1

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Description

MMP-2/9-IN-2 (Compound 6k) is a MMP-2 and MMP-9 inhibitor, with IC50 values of 29.27 and 24.87 μM respectively. MMP-2/9-IN-2 exhibits good selective toxicity against multiple human hepatoma cell lines. MMP-2/9-IN-2 induces cell cycle arrest and apoptosis, significantly inhibits cell migration and invasion. MMP-2/9-IN-2 inhibits the phosphorylation of the STAT3 signaling pathway. MMP-2/9-IN-2 shows strong anti-tumor activity in a nude mouse xenograft model of HepG2 liver cancer cells[1].

IC50 & Target[1]

MMP-2

29.27 μM (IC50)

MMP-9

24.87 μM (IC50)

STAT3

 

Molecular Weight

413.51

Formula

C23H31N3O4
SMILES

O=C(NCCCN(C)C)NC1=CC(/C=C\C2=CC(OC)=CC(OC)=C2)=CC=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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MMP-2/9-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-2/9-IN-2MMPSTATApoptosisMatrix metalloproteinasesResveratrol derivativeUrea backbone6kHepatocellular carcinomaSTAT3 signalingMetastasis inhibitionApoptosis inductionInhibitorinhibitorinhibit

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