Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model.
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- Formule: C22H22N2O4
- Masse moléculaire:378.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
STAT3 0.52 μM (IC50) |
NQO1 1.48 μM (IC50) |
Chemical Information
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Masse moléculaire 378.42
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Formule C22H22N2O4
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SMILES
O=C(C1=C(C2=C3C4=C(C(N(CCN5CCCCC5)CC4)=O)O2)C=CC=C1)C3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-195 Related Classifications
HY-170947 Related Classifications
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