Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model.
For research use only. We do not sell to patients.
- Formula: C22H22N2O4
- Molecular Weight:378.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
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STAT3 0.52 μM (IC50) |
NQO1 1.48 μM (IC50) |
Chemical Information
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Molecular Weight 378.42
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Formula C22H22N2O4
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SMILES
O=C(C1=C(C2=C3C4=C(C(N(CCN5CCCCC5)CC4)=O)O2)C=CC=C1)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-195 Related Classifications
HY-170947 Related Classifications
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