Sorafenib-d3 tosylate
Based on 1 publication(s) in Google Scholar
Sorafenib-d3 (Donafenib-d3) tosylate is the deuterium labeled Sorafenib (HY-10201). Sorafenib is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib-d3tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib-d3tosylate induces autophagy and apoptosis. Sorafenib-d3tosylate has anti-tumor activity. Sorafenib is a ferroptosis activator.
For research use only. We do not sell to patients.
- CAS No.: 1333386-17-6
- Formula: C28H21D3ClF3N4O6S
- Molecular Weight:640.05
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Sorafenib-d3 tosylate
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1333386-17-6
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Unlabeled Cas 475207-59-1
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Molecular Weight 640.05
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Formula C28H21D3ClF3N4O6S
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SMILES
O=S(O)(C1=CC=C(C=C1)C)=O.[2H]C([2H])([2H])NC(C2=CC(OC3=CC=C(C=C3)NC(NC4=CC(C(F)(F)F)=C(C=C4)Cl)=O)=CC=N2)=O
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Synonyms
Donafenib tosylate; Bay 43-9006-d3 tosylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sorafenib-d3 tosylate Related Classifications
HY-10201S4 Related Classifications
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