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Cat. No.: HY-112447

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STAT3-IN-5

STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC₅₀ value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No.: 1041438-68-9
Formula: C₁₉H₇F₇N₂O₃
Molecular Weight:444.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

STAT3-IN-5 Chemical Structure

CAS No.: 1041438-68-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

p-STAT3

170 nM (EC₅₀)

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U-266	EC₅₀	0.17 μM Compound: 8	Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis Inhibition of STAT3 Y705 phosphorylation in human U266 cells by Western blot analysis	[PMID: 18578470]

In Vitro

STAT3-IN-5 (compound 8; 0-2 μM; 1 h) inhibits STAT3 phosphorylation in U266 cells^[1].
STAT3-IN-5 (0-2 μM; 1 h) inhibits cytokines induced phosphorylation of JAK1, JAK2, and Tyk2 in U266 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

U266 cells
Concentration:

0-2 μM
Incubation Time:

1 hours
Result:

Inhibited cytokine induced phosphorylation of JAK1, JAK2, and Tyk2 (P-JAK1-Y1022/1023, P-JAK2-Y1007/1008, P-Tyk2-Y1054/1055).

Western Blot Analysis^[1]

Cell Line:

U266 cells
Concentration:

0-2 μM
Incubation Time:

1 hours
Result:

Inhibited STAT3 phosphorylation in a dose-dependent manner.

Chemical Information

CAS No. 1041438-68-9
Molecular Weight 444.26
Formula C₁₉H₇F₇N₂O₃
SMILES

N#CC1=C(C(F)=C(N2C=C(C(C3=CC(F)=C(C(F)=C32)F)=O)C(OCC)=O)C(F)=C1F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu J, et, al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem. 2008 Jul 24;51(14):4115-21. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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