15-Keto-prostaglandin E2-d₄

製品番号: HY-113205S1: Data Sheet 取扱説明書
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15-Keto-prostaglandin E2-d₄ is the deuterium labeled 15-Keto-prostaglandin E2.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

15-Keto-prostaglandin E2-d₄ 構造式

CAS 番号 : 2738376-85-5

容量		在庫状況
1 mg		お問い合わせ
5 mg		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of 15-Keto-prostaglandin E2-d₄:

15-keto-Prostaglandin E2 在庫あり

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•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
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製品説明

15-Keto-prostaglandin E2-d₄ is the deuterium labeled 15-Keto-prostaglandin E2^[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

354.47

分子式

C₂₀H₂₆D₄O₅

CAS 番号

2738376-85-5

Unlabeled CAS

26441-05-4

SMILES

O=C1[C@@H]([C@H]([C@@H](C1)O)/C=C/C(CCCCC)=O)C/C=C\C([2H])(C([2H])(CC(O)=O)[2H])[2H]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (282.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8211 mL	14.1056 mL	28.2111 mL
5 mM	0.5642 mL	2.8211 mL	5.6422 mL
10 mM	0.2821 mL	1.4106 mL	2.8211 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8211 mL	14.1056 mL	28.2111 mL	70.5278 mL
	5 mM	0.5642 mL	2.8211 mL	5.6422 mL	14.1056 mL
	10 mM	0.2821 mL	1.4106 mL	2.8211 mL	7.0528 mL
	15 mM	0.1881 mL	0.9404 mL	1.8807 mL	4.7019 mL
	20 mM	0.1411 mL	0.7053 mL	1.4106 mL	3.5264 mL
	25 mM	0.1128 mL	0.5642 mL	1.1284 mL	2.8211 mL
	30 mM	0.0940 mL	0.4702 mL	0.9404 mL	2.3509 mL
	40 mM	0.0705 mL	0.3526 mL	0.7053 mL	1.7632 mL
	50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4106 mL
	60 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1755 mL
	80 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8816 mL
	100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.7053 mL