15-Keto-prostaglandin E2-d4
15-Keto-prostaglandin E2-d4 is the d4 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
For research use only. We do not sell to patients.
- CAS No.: 2738376-85-5
- Formula: C20H26D4O5
- Molecular Weight:354.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
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PPARγ |
EP2 |
EP4 |
STAT3 |
Human Endogenous Metabolite |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2738376-85-5
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Unlabeled Cas 26441-05-4
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Molecular Weight 354.47
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Formula C20H26D4O5
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SMILES
O=C1[C@@H]([C@H]([C@@H](C1)O)/C=C/C(CCCCC)=O)C/C=C\C([2H])(C([2H])(CC(O)=O)[2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : ≥ 100 mg/mL (282.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022;310:121114. [Content Brief]
[2]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019;15(3):e1007597. Published 2019 Mar 28. [Content Brief]
[3]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019;23:101175. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8211 mL | 14.1056 mL | 28.2111 mL | 70.5278 mL |
| 5 mM | 0.5642 mL | 2.8211 mL | 5.6422 mL | 14.1056 mL | |
| 10 mM | 0.2821 mL | 1.4106 mL | 2.8211 mL | 7.0528 mL | |
| 15 mM | 0.1881 mL | 0.9404 mL | 1.8807 mL | 4.7019 mL | |
| 20 mM | 0.1411 mL | 0.7053 mL | 1.4106 mL | 3.5264 mL | |
| 25 mM | 0.1128 mL | 0.5642 mL | 1.1284 mL | 2.8211 mL | |
| 30 mM | 0.0940 mL | 0.4702 mL | 0.9404 mL | 2.3509 mL | |
| 40 mM | 0.0705 mL | 0.3526 mL | 0.7053 mL | 1.7632 mL | |
| 50 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4106 mL | |
| 60 mM | 0.0470 mL | 0.2351 mL | 0.4702 mL | 1.1755 mL | |
| 80 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8816 mL | |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2821 mL | 0.7053 mL |
15-Keto-prostaglandin E2-d4 Related Classifications
HY-113205S1 Related Classifications
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- 15-Keto-prostaglandin E2-d4
- 2738376-85-5
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Prostaglandin Receptor
- STAT
- PPAR
- Fungal
- Drug Metabolite
- PPAR-γ
- mammary epithelial cells
- Cryptococcus neoformans
- EP2 receptors
- zebrafish embryos
- STAT3
- BALB/c nude mice
- MDA-MB-231 cells
- EP4 receptors
- yeast models
- Inhibitor
- inhibitor
- inhibit