26441-05-4
Chemical Structure
15-keto-Prostaglandin E2
Synonym(s): 15-keto-PGE2
- CAS No.: 26441-05-4
- Formula:C20H30O5
- Molecular Weight:350.45
IUPAC Name: (Z)-7-((1R,2R,3R)-3-hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
InChIKey: YRTJDWROBKPZNV-KMXMBPPJSA-N
SMILES: CCCCCC(/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O)=O
Biological Activity: 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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15-keto-Prostaglandin E2 | 99.0% | 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier. | ||||||||||||||||||||
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15-Keto-prostaglandin E2-d4 | 15-Keto-prostaglandin E2-d4 is the d4 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier. | |||||||||||||||||||||
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15-Keto-prostaglandin E2-d9 | 99.9% | 15-Keto-prostaglandin E2-d9 is the d9 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier. The product specifications provided below refer solely to the active content of 15-Keto-prostaglandin E2-d9. |
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Similarity Score 1.00
HY-W3469768-Iso-15-keto prostaglandin E2 -
Similarity Score 0.82
HY-101952RProstaglandin E2 (Standard) -
Similarity Score 0.82
HY-118465ent-Prostaglandin E2 -
Similarity Score 0.82
HY-13022311β-Prostaglandin E2 -
Similarity Score 0.82
HY-1303048-Isoprostaglandin E2 -
Similarity Score 0.82
HY-13069415(R)-Prostaglandin E2 -
Similarity Score 0.82
HY-135023R5-trans-PGE2 (Standard) -
Similarity Score 0.82
HY-13711715-keto-PGE1 -
Similarity Score 0.81
HY-116843(15S)-15-Methylprostaglandin E2 -
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References
- [1]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022;310:121114. [Content Brief]
- [2]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019;15(3):e1007597. Published 2019 Mar 28. [Content Brief]
- [3]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019;23:101175. [Content Brief]
