15-Keto-prostaglandin E2-d9
Based on 1 Customer Validation
15-Keto-prostaglandin E2-d9 is the d9 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
For research use only. We do not sell to patients.
- CAS No.: 2738376-66-2
- Formula: C20H21D9O5
- Molecular Weight:359.50
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
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PPARγ |
EP2 |
EP4 |
STAT3 |
Human Endogenous Metabolite |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2738376-66-2
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Unlabeled Cas 26441-05-4
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Appearance Liquid
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Molecular Weight 359.50
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Formula C20H21D9O5
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SMILES
O=C1[C@@H]([C@H]([C@@H](C1)O)/C=C/C(CC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O)C/C=C\CCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Solvent & Solubility
DMSO : ≥ 100 mg/mL (278.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022;310:121114. [Content Brief]
[2]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019;15(3):e1007597. Published 2019 Mar 28. [Content Brief]
[3]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019;23:101175. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7816 mL | 13.9082 mL | 27.8164 mL | 69.5410 mL |
| 5 mM | 0.5563 mL | 2.7816 mL | 5.5633 mL | 13.9082 mL | |
| 10 mM | 0.2782 mL | 1.3908 mL | 2.7816 mL | 6.9541 mL | |
| 15 mM | 0.1854 mL | 0.9272 mL | 1.8544 mL | 4.6361 mL | |
| 20 mM | 0.1391 mL | 0.6954 mL | 1.3908 mL | 3.4771 mL | |
| 25 mM | 0.1113 mL | 0.5563 mL | 1.1127 mL | 2.7816 mL | |
| 30 mM | 0.0927 mL | 0.4636 mL | 0.9272 mL | 2.3180 mL | |
| 40 mM | 0.0695 mL | 0.3477 mL | 0.6954 mL | 1.7385 mL | |
| 50 mM | 0.0556 mL | 0.2782 mL | 0.5563 mL | 1.3908 mL | |
| 60 mM | 0.0464 mL | 0.2318 mL | 0.4636 mL | 1.1590 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3477 mL | 0.8693 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL | 0.6954 mL |
15-Keto-prostaglandin E2-d9 Related Classifications
HY-113205S Related Classifications
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- 15-Keto-prostaglandin E2-d9
- 2738376-66-2
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Prostaglandin Receptor
- STAT
- PPAR
- Fungal
- Drug Metabolite
- PPAR-γ
- mammary epithelial cells
- Cryptococcus neoformans
- EP2 receptors
- zebrafish embryos
- STAT3
- BALB/c nude mice
- MDA-MB-231 cells
- EP4 receptors
- yeast models
- Inhibitor
- inhibitor
- inhibit