1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. APTSTAT3-9R

APTSTAT3-9R 

Cat. No.: HY-P2282
Handling Instructions

APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

APTSTAT3-9R Chemical Structure

APTSTAT3-9R Chemical Structure

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Description

APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity[1].

IC50 & Target

STAT3

 

In Vitro

APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549)[1].
APTSTAT3-9R (30 μM; for 2 weeks) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. APTSTAT3-9R has IC50s of 10 to 20 μM in A549, B16F1 and HepG2 cells[1].
APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) effectively inhibits phosphorylation of STAT3 but does not affect the level of AKT phosphorylation, indicating specificity of the aptide[1].

In Vivo

APTSTAT3-9R (8 mg/kg in 50 μL; intratumorally injected every other day for a total of four injections) suppresses tumor growth in 6-week-old female BALB/c nude mice with A549 cells[1].

Molecular Weight

4947.51

Formula

C₂₂₃H₃₃₀N₈₀O₅₁

Sequence

His-Gly-Phe-Gln-Trp-Pro-Gly-Ser-Trp-Xaa-Trp-Glu-Asn-Gly-Lys-Trp-Xaa-Trp-Lys-Gly-Ala-Tyr-Gln-Phe-Leu-Lys-Gly-Gly-Gly-Gly-Ser-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Sequence Shortening

HGFQWPGSWXWENGKWXWKGAYQFLKGGGGSRRRRRRRRR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

APTSTAT3-9RSTATphosphorylationantiproliferativeantitumorhumanlungcarcinomacellsA549B16F1HepG2Inhibitorinhibitorinhibit

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APTSTAT3-9R
Cat. No.:
HY-P2282
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