2. Cell Cycle/DNA Damage Stem Cell/Wnt JAK/STAT Signaling
  3. CDK STAT
  4. Vanicoside B

Vanicoside B is a phenylpropanoyl sucrose derivative, can be isolated from the herb Persicaria dissitiflora. Vanicoside B targets cyclin-dependent kinase 8 (CDK8) and exhibits anti-tumor activity. The potential mechanism is Vanicoside B blocks CDK8-mediated signaling pathways and decreases the expression of epithelial-mesenchymal transition proteins, so that it leads to cell cycle arrest and apoptosis.

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Vanicoside B Chemical Structure

Vanicoside B Chemical Structure

CAS No. : 155179-21-8

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Vanicoside B Related Antibodies

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Description

Vanicoside B is a phenylpropanoyl sucrose derivative, can be isolated from the herb Persicaria dissitiflora. Vanicoside B targets cyclin-dependent kinase 8 (CDK8) and exhibits anti-tumor activity. The potential mechanism is Vanicoside B blocks CDK8-mediated signaling pathways and decreases the expression of epithelial-mesenchymal transition proteins, so that it leads to cell cycle arrest and apoptosis[1][2].

IC50 & Target[1]

CDK3

 

STAT3

 

In Vitro

Vanicoside B (2.5-20 μM; 72 h) shows antiproliferative activity against a panel of cancer cell lines in triple-negative breast cancer (TNBC) MDA-MB-231 cells and HCC38 cells[1].
Vanicoside B (2.5-20 μM; 72 h, 14 d, and 72 h, respectively) inhibits cell viability, colony formation, and disturbs cell cycle distribution in TNBC cells[1].
Vanicoside B (2.5-10 μM; 48 h) decreased p-STAT1, p-STAT3, and p-S6 protein level, and induces apoptosis by regulating the Skp2-p27 axis in TNBC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vanicoside B Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells and HCC38 cells
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 48 hours
Result: Increased cleaved PARP, and p27 protein expressions, but decreased Skp2 protein level.
Suppressed CDK8 target genes and the expression of EMT-associated proteins.
Suppressed the expression of the cell proliferation marker Ki-67 in tumor tissues, also significantly suppressed the expressions of p-STAT1 (S727) and AXL.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells and HCC38 cells
Concentration: 0, 2.5, 5, 10 μM
Incubation Time: 72 hours
Result: Inhibited cell cycle at sub-G1 phase.
In Vivo

Vanicoside B (5 mg/kg and 20 mg/kg; i.p.; 3 times per week for 4 weeks) inhibits tumor growth in xenografted mouse models with MDAMB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231 cell-implanted xenograft mouse model[1]
Dosage: 5 mg/kg, 20 mg/kg
Administration: Intraperitoneal injection; 3 times per week over 4 weeks
Result: Significantly reduced tumor volumes at 5 mg/kg and 20 mg/kg by 53.85% and 65.72%, respectively.
Molecular Weight

956.89

Formula

C49H48O20
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C=C1)=CC=C1/C=C/C(OC[C@@]2([C@H]([C@@H]([C@H](O2)COC(/C=C/C3=CC=C(C=C3)O)=O)O)OC(/C=C/C4=CC=C(C=C4)O)=O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)COC(/C=C/C6=CC(OC)=C(C=C6)O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Vanicoside B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vanicoside B155179-21-8CDKSTATCyclin dependent kinaseInhibitorinhibitorinhibit

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