Cat. No.: HY-N11003

Vanicoside A

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits protein kinase C (PKC), induces substantial ROS production. Vanicoside A exhibits anticancer activity against melanoma.

For research use only. We do not sell to patients.

Purity: 99.40%
CAS No.: 155179-22-9
Formula: C₅₁H₅₀O₂₁
Molecular Weight:998.93

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Vanicoside A Chemical Structure

CAS No.: 155179-22-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All PKC Isoforms :

In Vitro

Vanicoside A (2.5-100 µM; 24-72 h) significantly reduces the viability of C32 and A375 melanoma cells^[2].
Vanicoside A (2.5-100 µM; 24-72 h) induces substantial ROS production in C32 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

A375 (melanotic melanoma)
Concentration:

2.5 µM, 5 µM, 10 µM, 25 µM, 50 µM, 100 µM
Incubation Time:

24 h, 48 h, 72 h
Result:

Slightly decreased viability at low concentrations (<10 µM) but significantly reduced to 51-21% at ≥50 µM (72 h).

Chemical Information

CAS No. 155179-22-9
Appearance Solid
Molecular Weight 998.93
Formula C₅₁H₅₀O₂₁
Color White to off-white
SMILES

OC1=C(OC)C=C(/C=C/C(OC[C@H]2O[C@@H]([C@@H]([C@H]([C@@H]2O)O)OC(C)=O)O[C@@]3(O[C@@H]([C@H]([C@@H]3OC(/C=C/C4=CC=C(C=C4)O)=O)O)COC(/C=C/C5=CC=C(C=C5)O)=O)COC(/C=C/C6=CC=C(C=C6)O)=O)=O)C=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Plants

Analysis of Phenolic Compounds of Reynoutria sachalinensis and Reynoutria japonica Growing in the Russian Far East. [Abstract]

2024 Nov 27;13(23):3330. PMID: 39683123

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (100.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0011 mL

5.0054 mL

10.0107 mL

5 mM

0.2002 mL

1.0011 mL

2.0021 mL

10 mM

0.1001 mL

0.5005 mL

1.0011 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zimmermann ML, Sneden AT. Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum. J Nat Prod. 1994 Feb;57(2):236-42. [Content Brief]

[2]. Nawrot-Hadzik I, et al. Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis Against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1. Int J Mol Sci. 2020 Jun 29;21(13):4611. [Content Brief]

[3]. Nawrot-Hadzik I, et al. The combination of pro-oxidative acting vanicosides and GLUT1 inhibitor (WZB117) exerts a synergistic cytotoxic effect against melanoma cells. Fitoterapia. 2023 Dec;171:105702. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0011 mL	5.0054 mL	10.0107 mL	25.0268 mL
	5 mM	0.2002 mL	1.0011 mL	2.0021 mL	5.0054 mL
	10 mM	0.1001 mL	0.5005 mL	1.0011 mL	2.5027 mL
	15 mM	0.0667 mL	0.3337 mL	0.6674 mL	1.6685 mL
	20 mM	0.0501 mL	0.2503 mL	0.5005 mL	1.2513 mL
	25 mM	0.0400 mL	0.2002 mL	0.4004 mL	1.0011 mL
	30 mM	0.0334 mL	0.1668 mL	0.3337 mL	0.8342 mL
	40 mM	0.0250 mL	0.1251 mL	0.2503 mL	0.6257 mL
	50 mM	0.0200 mL	0.1001 mL	0.2002 mL	0.5005 mL
	60 mM	0.0167 mL	0.0834 mL	0.1668 mL	0.4171 mL
	80 mM	0.0125 mL	0.0626 mL	0.1251 mL	0.3128 mL
	100 mM	0.0100 mL	0.0501 mL	0.1001 mL	0.2503 mL

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Vanicoside A

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Publications Citing Use of MedChemExpress (MCE) Vanicoside A

All PKC Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Vanicoside A Related Classifications

Cat. No.: HY-N11003