15(R)-Lipoxin A4
Based on 1 Customer Validation
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease.
For research use only. We do not sell to patients.
- Purity: 98.3%
- CAS No.: 171030-11-8
- Formula: C20H32O5
- Molecular Weight:352.47
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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STAT6 |
STAT3 |
JNK1 |
JNK2 |
JNK3 |
ALOX12 |
COX-2 |
ALOX15 |
Human Endogenous Metabolite |
15 (R)-Lipoxin A4 (10 nM; 24 h) reduces the levels of proinflammatory eicosanoids and increases the levels of specific pro-resolving mediators in IL-1β-stimulated tendon matrix cells derived from tendinopathy[1].
15 (R)-Lipoxin A4 (10 nM; 24 h) reduces the levels of proinflammatory eicosanoids and increases the levels of pro-resolving mediators in tendon stromal cells derived from allergic rhinitis following stimulation with IL-1β[1].
15 (R)-Lipoxin A4 (10 nM; 24 h) upregulates the expressions of pro-resolving biosynthetic enzymes ALOX12, ALOX15 and receptor ALX in tendon stromal cells derived from tendinopathy and allergic rhinitis that are stimulated by IL-1β, and the mRNA level of ALOX15 increases significantly in both cell types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 171030-11-8
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Appearance Liquid
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Molecular Weight 352.47
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Formula C20H32O5
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Color Colorless to light yellow
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SMILES
CCCCC[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(O)=O
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Synonyms
15-epi-LXA4
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dakin SG, et al. 15-Epi-LXA4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture. FASEB J. 2019;33(7):8043-8054. [Content Brief]
[2]. Lee JY, et al. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun. 2018;9(1):1479. Published 2018 Apr 16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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