OSM-SMI-8
OSM-SMI-8 is an oncostatin M (OSM) inhibitor with a pKi of 44.82 nM against human targets. OSM-SMI-8 inhibits the activation of STAT3, JNK, ERK 42/44 and AKT signaling pathways induced by OSM. OSM-SMI-8 is applicable to research related to cancer metastasis and Crohn's disease.
For research use only. We do not sell to patients.
- CAS No.: 1689690-20-7
- Formula: C28H20N2O4S2
- Molecular Weight:512.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
STAT3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cancer cell lines | IC50 |
531 nM
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Inhibition of OSM-induced activity in cancer cells assessed via absorbance measurement at 540 nm after treatment with OSM (5 ng/mL) and varying concentrations of OSM-SMI-8.
Inhibition of OSM-induced activity in cancer cells assessed via absorbance measurement at 540 nm after treatment with OSM (5 ng/mL) and varying concentrations of OSM-SMI-8.
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en?oq=US9550828B2 |
In Vitro
OSM-SMI-8 inhibits OSM-induced detachment of prostate cancer cells[2].
OSM-SMI-8 inhibits OSM-induced pSTAT3 activation in cancer cells[2].
OSM-SMI-8 (531 μM; 30 min) inhibits the OSM-induced activation of STAT3, JNK, ERK 42/44 and AKT signaling pathways in MDA-MB-231 cells[2].
OSM-SMI-8 (2.44-2500 nM; 30 min) potently inhibits OSM-induced activity, with an IC50 of 531 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:531 μM
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Incubation Time:30 min
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Result:Inhibited OSM-induced activation of STAT3, JNK, ERK 42/44, and AKT signaling pathways.
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Cell Line:MDA-MB-231 cells
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Concentration:2.44, 9.77, 39.06, 156.25, 625, 2500 nM
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Incubation Time:30 min
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Result:Inhibited OSM-induced activity.
Chemical Information
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CAS No. 1689690-20-7
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Molecular Weight 512.60
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Formula C28H20N2O4S2
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SMILES
OC(/C(C1=CSC(C2=NC(/C(C(O)=O)=C/C=C/C3=CC=CC=C3)=CS2)=N1)=C\C=C\C4=CC=CC=C4)=O
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Synonyms
NSC642624
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OSM-SMI-8 Related Classifications
HY-148693 Related Classifications
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