1689690-20-7
1689690-20-7
Chemical Structure
OSM-SMI-8
Synonym(s): NSC642624
- CAS No.: 1689690-20-7
- Formula:C28H20N2O4S2
- Molecular Weight:512.60
IUPAC Name: 6-bromo-3-fluoro-2-(fluoromethyl)pyridine
InChIKey: UJBUSAZATHWVAW-AEPXBALGSA-N
SMILES: OC(/C(C1=CSC(C2=NC(/C(C(O)=O)=C/C=C/C3=CC=CC=C3)=CS2)=N1)=C\C=C\C4=CC=CC=C4)=O
Biological Activity: OSM-SMI-8 is an oncostatin M (OSM) inhibitor with a pKi of 44.82 nM against human targets. OSM-SMI-8 inhibits the activation of STAT3, JNK, ERK 42/44 and AKT signaling pathways induced by OSM. OSM-SMI-8 is applicable to research related to cancer metastasis and Crohn's disease[1][2].
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OSM-SMI-8 | OSM-SMI-8 is an oncostatin M (OSM) inhibitor with a pKi of 44.82 nM against human targets. OSM-SMI-8 inhibits the activation of STAT3, JNK, ERK 42/44 and AKT signaling pathways induced by OSM. OSM-SMI-8 is applicable to research related to cancer metastasis and Crohn's disease. | |||||||||||||||||||||
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References
- [1]. Bahramimehr F, et al. Drug Repurposing to Inhibit Oncostatin M in Crohn's Disease. Molecules (Basel, Switzerland). 2025 Apr 24;30(9):1897.
- [2]. Jorcyk C, et al. Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders. US9550828B2. United States Patent and Trademark Office. 2017-01-24.
Keywords
