2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt MAPK/ERK Pathway
  3. Apoptosis JAK STAT p38 MAPK JNK ERK
  4. Cernuumolide J

Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.

For research use only. We do not sell to patients.

Cernuumolide J

Cernuumolide J Chemical Structure

CAS No. : 2019163-02-9

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Cernuumolide J Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

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Description

Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy[1].

IC50 & Target

JNK3

 

Stat-3

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
18.36 μM
Compound: 10
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27668963]
A549 IC50
4.7 μM
Compound: 20
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay
[PMID: 30869892]
HCT-116 IC50
5.51 μM
Compound: 10
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27668963]
HL-60 IC50
3 μM
Compound: 20
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay
[PMID: 30869892]
MDA-MB-231 IC50
7.53 μM
Compound: 10
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27668963]
Molecular Weight

450.52

Formula

C24H34O8
CAS No.
SMILES

CC(C)C(O[C@@H]1[C@]2([H])[C@@](C(C(O2)=O)=C)([H])[C@@H](C([C@@H](CCC[C@@]1(O)C)C)=O)OC(/C(C)=C\C)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cernuumolide J Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cernuumolide J2019163-02-9TMJ-105TMJ105TMJ 105ApoptosisJAKSTATp38 MAPKJNKERKJanus kinasec-Jun N-terminal kinaseExtracellular signal regulated kinasesHEL leukemia cellInhibitorinhibitorinhibit

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