1. MAPK/ERK Pathway
    Protein Tyrosine Kinase/RTK
    Apoptosis
    Autophagy
  2. Raf
    VEGFR
    FLT3
    Ferroptosis
    Autophagy
    Apoptosis
  3. Sorafenib (D4)

Sorafenib (D4) (Synonyms: Bay 43-9006 (D4))

Cat. No.: HY-10201S1
Handling Instructions

Sorafenib D4 (Bay 43-9006 D4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

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Sorafenib (D4) Chemical Structure

Sorafenib (D4) Chemical Structure

CAS No. : 1207560-07-3

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Description

Sorafenib D4 (Bay 43-9006 D4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

Molecular Weight

468.85

Formula

C₂₁H₁₂D₄ClF₃N₄O₃

CAS No.

1207560-07-3

SMILES

O=C(C1=NC=CC(OC2=C([2H])C([2H])=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C([2H])=C2[2H])=C1)NC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Sorafenib (D4)Bay 43-9006 (D4)RafVEGFRFLT3FerroptosisAutophagyApoptosisRaf kinasesVascular endothelial growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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