PROTAC STAT3 degrader-2
PROTAC STAT3 degrader-2 is a PROTAC degrader that targets STAT3, with a DC50 value of 3.54 μM. PROTAC STAT3 degrader-2 inhibits the growth of leukemia and lymphoma cells with high levels of phosphorylated STAT3. PROTAC STAT3 degrader-2 is used in the research of acute myeloid leukemia and anaplastic large cell lymphoma.
(Pink: STAT3 ligand (HY-187011); Blue: Cereblon ligand (HY-W039116); Black: linker (HY-69220)).
For research use only. We do not sell to patients.
- CAS No.: 2429877-78-9
- Formula: C59H60F2N9O13P
- Molecular Weight:1172.13
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
IC50 & Target
[1]|
STAT3 3.54 μM (ID50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SU-DHL-1 | IC50 |
>10 μM
Compound: 27
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Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay
Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay
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[PMID: 31747516] |
In Vitro
PROTAC STAT3 degrader-2 (Compound 27) (4 h) degrades total STAT3 protein in Molm-16 human acute myeloid leukemia cells, with a STAT3 degradation DC50 value of 3.54 μM[1].
PROTAC STAT3 degrader-2 (4 days) exhibits a cell growth inhibitory IC50 value of 0.582 μM in Molm-16 human acute myeloid leukemia cells[1].
PROTAC STAT3 degrader-2 (Up to 5 μM) is ineffective at degrading STAT3 protein in SU-DHL-1 human anaplastic large cell lymphoma cells after 16 hours of treatment[1].
PROTAC STAT3 degrader-2 (Up to 10 μM) has no measurable growth inhibitory activity against SU-DHL-1 human anaplastic large cell lymphoma cells after 4 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SU-DHL-1 anaplastic large cell lymphoma cell line
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Concentration:Up to 5 μM
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Incubation Time:16 h
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Result:Does not reduce total STAT3 or pSTAT3 (Y705) protein levels in SU-DHL-1 cells at concentrations up to 5 μM.
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Cell Line:SU-DHL-1 anaplastic large cell lymphoma cell line
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Concentration:Up to 10 μM
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Incubation Time:4 days
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Result:Does not inhibit SU-DHL-1 cell growth at concentrations up to 10 μM.
Chemical Information
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CAS No. 2429877-78-9
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Appearance Solid
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Molecular Weight 1172.13
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Formula C59H60F2N9O13P
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Color White to off-white
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SMILES
O=C1C2=C(C#CCCCCCC(N3C[C@@H](C(N4[C@@](CC[C@H]4C(N[C@@H](CCC(N)=O)C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)=O)([H])CC3)=O)NC(C7=CC8=CC(C(F)(F)P(O)(O)=O)=CC=C8N7)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC STAT3 degrader-2 Related Classifications
HY-153023 Related Classifications
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