PROTAC STAT3 degrader-2
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research. PROTAC STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2429877-78-9
- Formula: C59H60F2N9O13P
- Molecular Weight:1172.13
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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STAT3 3.54 μM (ID50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SU-DHL-1 | IC50 |
>10 μM
Compound: 27
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Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay
Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay
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[PMID: 31747516] |
PROTAC STAT3 degrader-2 (compound 27; 4 days) has cell growth-inhibitory activities in the Molm-16 with an IC50 of 0.582 μM and has no effect on SU-DHL-1 cell lines with an IC50 of >10 μM, respectively[1].
PROTAC STAT3 degrader-2 is ineffective in reducing the levels of STAT3 and pSTATSY705 proteins in SU-DHL-1 cells up to 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2429877-78-9
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Appearance Solid
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Molecular Weight 1172.13
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Formula C59H60F2N9O13P
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Color White to off-white
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SMILES
O=C1C2=C(C#CCCCCCC(N3C[C@@H](C(N4[C@@](CC[C@H]4C(N[C@@H](CCC(N)=O)C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)=O)([H])CC3)=O)NC(C7=CC8=CC(C(F)(F)P(O)(O)=O)=CC=C8N7)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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