EGFR/STAT3-IN-2
EGFR/STAT3-IN-2 is an inhibitor of EGFR tyrosine kinase and STAT3 signaling. EGFR/STAT3-IN-2 induces Apoptosis and G0/G1 cell cycle arrest. EGFR/STAT3-IN-2 exhibits selective anticancer activity against lung adenocarcinoma. EGFR/STAT3-IN-2 can be used for research on non-small cell lung cancer.
For research use only. We do not sell to patients.
- Formula: C17H11BrClN3O2S
- Molecular Weight:436.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
[1]|
STAT3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
33.85 μM
|
Cytotoxicity against human A549 lung adenocarcinoma cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against human A549 lung adenocarcinoma cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
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42612271 |
| L929 | IC50 |
>500 μM
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Cytotoxicity against mouse L929 embryonic fibroblast cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against mouse L929 embryonic fibroblast cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
|
42612271 |
| A549 | IC50 |
22.25 μM
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Inhibition of EGFR in human A549 lung adenocarcinoma cells incubated for 24 hrs by colorimetric In-Cell ELISA.
Inhibition of EGFR in human A549 lung adenocarcinoma cells incubated for 24 hrs by colorimetric In-Cell ELISA.
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42612271 |
| A549 | IC50 |
3.48 μM
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Inhibition of STAT3 in human A549 lung adenocarcinoma cells incubated for 24 hrs by colorimetric In-Cell ELISA.
Inhibition of STAT3 in human A549 lung adenocarcinoma cells incubated for 24 hrs by colorimetric In-Cell ELISA.
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42612271 |
In Vitro
EGFR/STAT3-IN-2 (Compound 2e) exhibits selective cytotoxicity against A549 lung adenocarcinoma cells with an IC50 of 33.85 μM[1].
EGFR/STAT3-IN-2 (33.85 μM; 24 h) induces apoptosis in A549 cells, with an early apoptosis rate of 22.52% and a late apoptosis rate of 3.12% at its IC50 concentration[1].
EGFR/STAT3-IN-2 (33.85 μM; 24 h) induces G0/G1 cell cycle arrest in A549 cells, with 69.99% of cells in the G0/G1 phase[1].
EGFR/STAT3-IN-2 (24 h) acts as a dual inhibitor of EGFR (IC50 = 22.25 μM) and STAT3 (IC50 = 3.48 μM) in A549 cells, with no activity against Akt[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:IC50 concentration
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Incubation Time:24 h
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Result:Resulted in 22.52% of A549 cells undergoing early apoptosis.
Resulted in 3.12% of A549 cells undergoing late apoptosis.
Induced total apoptosis of 25.64%.
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Cell Line:A549
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Concentration:IC50 concentration
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Incubation Time:24 h
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Result:Resulted in a G0/G1 phase cell population of 69.99%.
Resulted in an S phase population of 18.04%.
Resulted in a G2/M phase population of 1.87%.
Chemical Information
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Molecular Weight 436.71
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Formula C17H11BrClN3O2S
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SMILES
ClC1=CC=C(C2=CSC(N/N=C/C3=C(Br)C=C(OCO4)C4=C3)=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/STAT3-IN-2 Related Classifications
HY-189465 Related Classifications
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