2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. UT-105

UT-105 is an orally active androgen receptor (AR) degrader. UT-105 binds to the N-terminal domain of AR and promotes its degradation. UT-105 inhibits the growth of enzalutamide-resistant breast cancer xenografts and reduces tumor cell proliferation. UT-105 can be used in the research of estrogen receptor-positive breast cancer.

For research use only. We do not sell to patients.

UT-105

UT-105 Chemical Structure

CAS No. : 2388536-21-6

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UT-105 Related Antibodies

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Description

UT-105 is an orally active androgen receptor (AR) degrader. UT-105 binds to the N-terminal domain of AR and promotes its degradation. UT-105 inhibits the growth of enzalutamide-resistant breast cancer xenografts and reduces tumor cell proliferation. UT-105 can be used in the research of estrogen receptor-positive breast cancer[1].

In Vivo

UT-105 (30 mg/kg; p.o.; daily; 30 days) significantly inhibits the growth of enzalutamide-resistant ER-positive breast cancer xenografts by reducing AR expression and tumor cell proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice (6-8 week old female; orthotopic patient-derived xenograft model, enobosarm-resistant)[1]
Dosage: 30 mg/kg
Administration: p.o.; daily; 30 days
Result: Significantly inhibited growth of enobosarm-resistant WHIM23 tumors compared to vehicle- and enzalutamide-treated tumors.
Reduced percent change in tumor volume from day 0 significantly lower than vehicle controls.
Reduced AR protein levels in tumors.
Resulted in very low tumor cell proliferation measured by Ki67 immunohistochemistry.
Molecular Weight

364.28

Formula

C15H11F3N6O2
CAS No.
SMILES

N#CC(C=N1)=CN1C[C@](C)(O)C(NC2=CN=C(C#N)C(C(F)(F)F)=C2)=O
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References
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UT-105 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UT-1052388536-21-6UT105UT 105Androgen Receptorandrogen receptorN-terminal domaintumor cell proliferationenobosarm-resistant breast cancer xenograftsER-positive breast cancerInhibitorinhibitorinhibit

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