PROTAC STAT3 HiBiT degrader-1
PROTAC STAT3 HiBiT degrader-1 (I-1) is a heterobifunctional STAT3 HiBiT PROTAC degrader, with DC50 < 0.05 μM (A549 cells). STAT3 HiBiT degrader 1 recruits STAT3 to an E3 ubiquitin ligase for ubiquitination and subsequent degradation. STAT3 HiBiT degrader 1 can be used for breast cancer research.
(Pink: STAT3 ligand (HY-169361); Blue: Cereblon ligand (HY-W382038); Black: linker).
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- CAS No.: 2767166-30-1
- Formule: C58H63F4N10O14PS
- Masse moléculaire:1263.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
STAT3 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2767166-30-1
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Masse moléculaire 1263.21
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Formule C58H63F4N10O14PS
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SMILES
FC(F)(P(O)(O)=O)C1=CC(C=C(C(N[C@H]2CN(C(OC)=O)CC[C@@H]3N([C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N4CCC(CCC#CC5=CC(N(C)C(N6C7C(NC(CC7)=O)=O)=O)=C6C=C5)CC4)=O)CC8=CC=C(F)C(F)=C8)=O)=O)CC3)C2=O)=O)S9)=C9C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC STAT3 HiBiT degrader-1 Related Classifications
HY-169370 Related Classifications
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