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Cat. No.: HY-169370

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PROTAC STAT3 HiBiT degrader-1

PROTAC STAT3 HiBiT degrader-1 (I-1) is a heterobifunctional STAT3 HiBiT PROTAC degrader, with DC₅₀ < 0.05 μM (A549 cells). STAT3 HiBiT degrader 1 recruits STAT3 to an E3 ubiquitin ligase for ubiquitination and subsequent degradation. STAT3 HiBiT degrader 1 can be used for breast cancer research.
(Pink: STAT3 ligand (HY-169361); Blue: Cereblon ligand (HY-W382038); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2767166-30-1
Formula: C₅₈H₆₃F₄N₁₀O₁₄PS
Molecular Weight:1263.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

PROTAC STAT3 HiBiT degrader-1 Chemical Structure

CAS No.: 2767166-30-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC STAT3 HiBiT degrader-1 (I-1) is a heterobifunctional STAT3 HiBiT PROTAC degrader, with DC₅₀ < 0.05 μM (A549 cells). STAT3 HiBiT degrader 1 recruits STAT3 to an E3 ubiquitin ligase for ubiquitination and subsequent degradation. STAT3 HiBiT degrader 1 can be used for breast cancer research^[1]. (Pink: STAT3 ligand (HY-169361); Blue: Cereblon ligand (HY-W382038); Black: linker).

IC₅₀ & Target

^[1]

STAT3

All PROTACs Isoforms :

All STAT Isoforms :

In Vitro

PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and intracellular E3 ubiquitin ligase into close proximity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS No. 2767166-30-1
Molecular Weight 1263.21
Formula C₅₈H₆₃F₄N₁₀O₁₄PS
SMILES

FC(F)(P(O)(O)=O)C1=CC(C=C(C(N[C@H]2CN(C(OC)=O)CC[C@@H]3N([C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N4CCC(CCC#CC5=CC(N(C)C(N6C7C(NC(CC7)=O)=O)=O)=C6C=C5)CC4)=O)CC8=CC=C(F)C(F)=C8)=O)=O)CC3)C2=O)=O)S9)=C9C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bin Yang, et al. Stat degraders and uses thereof. US20240293423A1. 2024-09-05.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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