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OGDHL - oxoglutarate dehydrogenase L Gene

Also Known as YOBELN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55753

About OGDHL

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:49,734,641-49,762,379 (from NCBI)

This gene has 6 transcripts (splice variants), 177 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 82.8), liver (RPKM 20.1) and 3 other tissues.

Summary

The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the Akt signaling cascade and can suppress the growth of cervical Cancer cells. [provided by RefSeq, Dec 2016]

OGDHL Products (11)

mRNA	Protein	Name
NM_001143996.2	NP_001137468.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform b
NM_001143997.2	NP_001137469.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform c
NM_001347819.1	NP_001334748.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform a
NM_001347820.1	NP_001334749.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform b
NM_001347821.2	NP_001334750.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform c
NM_001347822.1	NP_001334751.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform c
NM_001347823.1	NP_001334752.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform d
NM_001347824.2	NP_001334753.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform d
NM_001347825.2	NP_001334754.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform e
NM_001347826.1	NP_001334755.1	2-oxoglutarate dehydrogenase-like, mitochondrial isoform f
NM_018245.3	NP_060715.2	2-oxoglutarate dehydrogenase-like, mitochondrial isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	23152800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGDHL Protein Structure

E1_dh

Transket_pyr

0
200
400
600
800
1010 a.a.

Protein Preferred Names	Protein Names
2-oxoglutarate dehydrogenase-like, mitochondrial	2-oxoglutarate dehydrogenase complex component E1-like

OGDHL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OGDHL	Q9ULD0	CDK4	Homo sapiens	P11802	Y2H Prey Pooling	32296183
Intra	OGDHL	Q9ULD0	CDK4	Homo sapiens	P11802	Y2H Array	32296183
Intra	OGDHL	Q9ULD0	STAT3	Homo sapiens	P40763	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Yoon-Bellen Neurodevelopmental Syndrome	YOBELN
Vertebral Anomalies And Variable Endocrine And T-Cell Dysfunction	VETD Heterozygotes For Tbx2 Variants
Charcot-Marie-Tooth Disease, Axonal, Type 2q	Charcot-Marie-Tooth Disease Axonal Type 2q CMT2Q Charcot-Marie-Tooth Neuropathy, Type 2q Autosomal Dominant Charcot-Marie-Tooth Disease Type 2q Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2q Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2q Charcot-Marie-Tooth Neuropathy Type 2q Charcot-Marie-Tooth Disease 2q Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2q Charcot-Marie-Tooth Neuropathy Axonal Type 2q
Dyskeratosis Congenita, Autosomal Recessive 2	DKCB2 Autosomal Recessive Dyskeratosis Congenita 2 Dyskeratosis Congenita, Autosomal Recessive, 2 Dyskeratosis Congenita, Autosomal Recessive, Type 2
Lissencephaly 6	Lis6
Fibroosseous Pseudotumor Of Digits	Fibroosseous Digital Pseudotumor Fibroosseous Pseudotumor Of The Digits
Immunodeficiency 18	IMD18 Cd3-Epsilon Deficiency Immunodeficiency 18, Scid Variant Cd3epsilon Deficiency Immunodeficiency 18, Severe Combined Immunodeficiency Variant Immunodeficiency, Type 18
Myasthenic Syndrome, Congenital, 6, Presynaptic	Familial Infantile Myasthenia CMS6 Cmsea Congenital Myasthenic Syndrome 6 Familial Infantile Myasthenia Gravis 2 Fimg2 Myasthenic Syndrome, Congenital, Associated With Episodic Apnea Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea Congenital Myasthenic Syndrome Type Ia2, Formerly Cms1a2, Formerly Cms Ia2, Formerly Myasthenia, Familial Infantile, Formerly Fim, Formerly Myasthenia Gravis, Familial Infantile, 2, Formerly Fimg2, Formerly Cms Ia2 Cms1a2 Congenital Myasthenic Syndrome 6, Presynaptic Congenital Myasthenic Syndrome Type Ia2 Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea Fim Cms1a Cms-Ea Cms Ia Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea Congenital Myasthenic Syndrome Type 1a Congenital Myasthenic Syndrome Type Ia Myasthenic Syndrome, Congenital, Type 6, Presynaptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09759	OGDHL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22700	Ogdhl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29214	Ogdhl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OGDHL	MGD	MGI:3616088
Bos taurus	OGDHL	VGNC	VGNC:32407
Macaca mulatta	OGDHL	VGNC	VGNC:81490
Rattus norvegicus	OGDHL	RGD	RGD:1310916
Felis catus	OGDHL	VGNC	VGNC:97544
Canis familiaris	OGDHL	VGNC	VGNC:44104