1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

HO-3867 

Cat. No.: HY-100453 Purity: 99.38%
Handling Instructions

HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor.

For research use only. We do not sell to patients.

HO-3867 Chemical Structure

HO-3867 Chemical Structure

CAS No. : 1172133-28-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

    HO-3867 purchased from MCE. Usage Cited in: JCI Insight. 2018 Sep 6;3(17). pii: 120750.

    A431 cells are then treated in full growth media with vehicle, CSA (50 ng/mL), Ruxolitinib (20 μM), or both Ruxolitinib and CSA for 36 hours.

    View All STAT Isoform Specific Products:

    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor.

    IC50 & Target[1]

    STAT3

     

    In Vitro

    HO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells. HO-3867 inhibit cell migration/invasion and survival by inhibiting STAT3 phosphorylation[1]. BRCA-mutated ovarian cancer cells treated with HO-3867 exhibited a significant degree of apoptosis with elevated levels of cleaved caspase-3, caspase-7 and PARP[2]. HO-3867 shows good antitumor activity at the concentration of 2 μmol/L in PANC-1 and BXPC-3 cells. Importantly, it is also found that HO-3867 treatment significantly induced reactive oxygen species (ROS) production in human pancreatic cancer cell lines, inducing PANC-1 and BXPC-3 cells[3].

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (68.88 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1526 mL 10.7631 mL 21.5262 mL
    5 mM 0.4305 mL 2.1526 mL 4.3052 mL
    10 mM 0.2153 mL 1.0763 mL 2.1526 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    464.55

    Formula

    C₂₈H₃₀F₂N₂O₂

    CAS No.

    1172133-28-6

    SMILES

    O=C1/C(CN(CC2=CC(C)(C)N(O)C2(C)C)C/C1=C\C3=CC=C(F)C=C3)=C/C4=CC=C(F)C=C4

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    HO-3867
    Cat. No.:
    HY-100453
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    HO-3867

    Cat. No.: HY-100453