1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

HO-3867 

Cat. No.: HY-100453 Purity: 99.38%
Handling Instructions

HO-3867 a selective and potent inhibit STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.

For research use only. We do not sell to patients.

HO-3867 Chemical Structure

HO-3867 Chemical Structure

CAS No. : 1172133-28-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

HO-3867 a selective and potent inhibit STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. target: STAT3 In vitro: HO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells. HO-3867 inhibit cell migration/invasion and survival by inhibiting STAT3 phosphorylation. [1] BRCA-mutated ovarian cancer cells treated with HO-3867 exhibited a significant degree of apoptosis with elevated levels of cleaved caspase-3, caspase-7 and PARP. [2] HO-3867/cisplatin combination treatment significantly inhibited cisplatin-resistant cell proliferation. [3]

References
Molecular Weight

464.55

Formula

C₂₈H₃₀F₂N₂O₂

CAS No.

1172133-28-6

SMILES

O=C1/C(CN(CC2=CC(C)(C)N(O)C2(C)C)C/C1=C\C3=CC=C(F)C=C3)=C/C4=CC=C(F)C=C4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
HO-3867
Cat. No.:
HY-100453
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