Bufothionine
Bufothionine is an alkaloid. Bufothionine can be isolated from Cinobufacini. Bufothionine induces mitochondria-mediated Apoptosis. Bufothionine significantly reduces serum IL-6 concentration, suppresses p-Stat3tyr705, p-Stat3ser727 and Jak2 expressions. Bufothionine upregulates Atg5, Atg7 and LC3Ⅱ expressions. Bufothionine induces Autophagy. Bufothionine suppresses PIM3 expression. Bufothionine relieves symptoms of H22-tumor-bearing mice and exerts anti-inflammation activity. Bufothionine exerts anti-cancer activities against gastric cancer.
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- CAS No.: 475-39-8
- Formula: C12H14N2O4S
- Molecular Weight:282.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK2 |
p-STAT3 |
PIM3 |
IL-6 |
Chemical Information
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CAS No. 475-39-8
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Molecular Weight 282.32
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Formula C12H14N2O4S
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SMILES
O=S([O-])(OC1=CC=C2NC=C3C2=C1[N+](C)(CC3)C)=O
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Structure Classification
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Initial Source
toad
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kong WS, et al. Bufothionine induces autophagy in H22 hepatoma-bearing mice by inhibiting JAK2/STAT3 pathway, a possible anti-cancer mechanism of cinobufacini. J Ethnopharmacol. 2021 Apr 24;270:113848. [Content Brief]
[2]. Wang G, et al. Bufothionine exerts anti-cancer activities in gastric cancer through Pim3. Life Sci. 2019 Sep 1;232:116615. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bufothionine Related Classifications
HY-N13352 Related Classifications
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