475-39-8
Chemical Structure
Bufothionine
- CAS No.: 475-39-8
- Formula:C12H14N2O4S
- Molecular Weight:282.32
InChIKey: VANPWLVSXXJWMF-UHFFFAOYSA-N
SMILES: O=S([O-])(OC1=CC=C2NC=C3C2=C1[N+](C)(CC3)C)=O
Biological Activity: Bufothionine is an alkaloid. Bufothionine can be isolated from Cinobufacini. Bufothionine induces mitochondria-mediated Apoptosis. Bufothionine significantly reduces serum IL-6 concentration, suppresses p-Stat3tyr705, p-Stat3ser727 and Jak2 expressions. Bufothionine upregulates Atg5, Atg7 and LC3Ⅱ expressions. Bufothionine induces Autophagy. Bufothionine suppresses PIM3 expression. Bufothionine relieves symptoms of H22-tumor-bearing mice and exerts anti-inflammation activity. Bufothionine exerts anti-cancer activities against gastric cancer[1][2].
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Bufothionine | Bufothionine is an alkaloid. Bufothionine can be isolated from Cinobufacini. Bufothionine induces mitochondria-mediated Apoptosis. Bufothionine significantly reduces serum IL-6 concentration, suppresses p-Stat3tyr705, p-Stat3ser727 and Jak2 expressions. Bufothionine upregulates Atg5, Atg7 and LC3Ⅱ expressions. Bufothionine induces Autophagy. Bufothionine suppresses PIM3 expression. Bufothionine relieves symptoms of H22-tumor-bearing mice and exerts anti-inflammation activity. Bufothionine exerts anti-cancer activities against gastric cancer. | |||||||||||||||||||||
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References
- [1]. Kong WS, et al. Bufothionine induces autophagy in H22 hepatoma-bearing mice by inhibiting JAK2/STAT3 pathway, a possible anti-cancer mechanism of cinobufacini. J Ethnopharmacol. 2021 Apr 24;270:113848. [Content Brief]
- [2]. Wang G, et al. Bufothionine exerts anti-cancer activities in gastric cancer through Pim3. Life Sci. 2019 Sep 1;232:116615. [Content Brief]
