MORC4 - MORC family CW-type zinc finger 4 Gene

Homo sapiens

Also known as ZCW4; ZCWCC2; dJ75H8.2

Gene ID: 79710 | Gene type: protein coding

About MORC4

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,940,738-107,000,212 (from NCBI)

This gene has 4 transcripts (splice variants), 314 orthologues and 1 paralogue. Broad expression in placenta (RPKM 38.5), adrenal (RPKM 15.2) and 18 other tissues.

Summary

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

MORC4 Products(2)

mRNA	Protein	Name
NM_001085354.3	NP_001078823.1	MORC family CW-type zinc finger protein 4 isoform b
NM_024657.5	NP_078933.3	MORC family CW-type zinc finger protein 4 isoform a

MORC4 Protein Structure

HATPase_c_3

zf-CW

0
200
400
600
800
937 a.a.

Protein Preferred Names

Protein Names

MORC family CW-type zinc finger protein 4

zinc finger CW-type coiled-coil domain protein 2

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z	Charcot-Marie-Tooth Disease Axonal Type 2z
Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z	Charcot-Marie-Tooth Neuropathy, Type 2z
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z	Charcot-Marie-Tooth Neuropathy Type 2z
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation
Charcot-Marie-Tooth Disease 2z	Charcot-Marie-Tooth Disease, Type 2z

Lynch Syndrome I

Lynch Syndrome 1	Colorectal Cancer, Hereditary Nonpolyposis, Type 1
HNPCC1	Fcc1
Lynch Syndrome Ii	Colon Cancer, Familial Nonpolyposis, Type 1
Coca1	Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colorectal Cancer Type 1	Hereditary Non-Polyposis Colorectal Cancer 1
Hereditary Non-Polyposis Colorectal Cancer 3	Hnpcc3
Lynch Cancer Family Syndrome	Lynch Syndrome
Lynch Syndrome Type I	Lynch Syndrome Type Ii
Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1	Hereditary Nonpolyposis Colorectal Cancer
Colorectal Cancer, Hereditary Nonpolyposis, Type 3	Hereditary Non-Polyposis Colon Cancer Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08592	MORC4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MORC4	RGD	RGD:1559905
Mus musculus	MORC4	MGD	MGI:1922996
Macaca mulatta	MORC4	VGNC	VGNC:74808
Canis familiaris	MORC4	VGNC	VGNC:43319
Felis catus	MORC4	VGNC	VGNC:63559

Name
Email *

	Sorry, but the email address you supplied was invalid.