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MORC4 - MORC family CW-type zinc finger 4 Gene

Also Known as ZCW4; ZCWCC2; dJ75H8.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79710

About MORC4

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,940,738-107,000,212 (from NCBI)

This gene has 4 transcripts (splice variants), 314 orthologues and 1 paralogue. Broad expression in placenta (RPKM 38.5), adrenal (RPKM 15.2) and 18 other tissues.

Summary

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

MORC4 Products (2)

mRNA	Protein	Name
NM_001085354.3	NP_001078823.1	MORC family CW-type zinc finger protein 4 isoform b
NM_024657.5	NP_078933.3	MORC family CW-type zinc finger protein 4 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	26933034	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORC4 Protein Structure

HATPase_c_3

zf-CW

0
200
400
600
800
937 a.a.

Protein Preferred Names	Protein Names
MORC family CW-type zinc finger protein 4	zinc finger CW-type coiled-coil domain protein 2

MORC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MORC4	Q8TE76	STAT3	Homo sapiens	P40763	Pull Down	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2z	CMT2Z Charcot-Marie-Tooth Disease Axonal Type 2z Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z Charcot-Marie-Tooth Neuropathy, Type 2z Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z Charcot-Marie-Tooth Neuropathy Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation Charcot-Marie-Tooth Disease 2z Charcot-Marie-Tooth Disease, Type 2z
Lynch Syndrome I	Lynch Syndrome 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 HNPCC1 Fcc1 Lynch Syndrome Ii Colon Cancer, Familial Nonpolyposis, Type 1 Coca1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Type 1 Hereditary Non-Polyposis Colorectal Cancer 1 Hereditary Non-Polyposis Colorectal Cancer 3 Hnpcc3 Lynch Cancer Family Syndrome Lynch Syndrome Lynch Syndrome Type I Lynch Syndrome Type Ii Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1 Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer, Hereditary Nonpolyposis, Type 3 Hereditary Non-Polyposis Colon Cancer Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08592	MORC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MORC4	RGD	RGD:1559905
Mus musculus	MORC4	MGD	MGI:1922996
Macaca mulatta	MORC4	VGNC	VGNC:74808
Canis familiaris	MORC4	VGNC	VGNC:43319
Felis catus	MORC4	VGNC	VGNC:63559
Others	MORC4	NCBI