1. JAK/STAT Signaling
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. STAT
    Phosphatase
  3. Isocryptotanshinone

Isocryptotanshinone 

Cat. No.: HY-N6651 Purity: >98.0%
Handling Instructions

Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.

For research use only. We do not sell to patients.

Isocryptotanshinone Chemical Structure

Isocryptotanshinone Chemical Structure

CAS No. : 22550-15-8

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Description

Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.

IC50 & Target[1][2]

STAT3

 

PTP1B

56.1 μM (IC50)

In Vitro

It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1].

Molecular Weight

296.36

Formula

C₁₉H₂₀O₃

CAS No.

22550-15-8

SMILES

O=C1C2=C(C3=C(C=C2)C(C)(C)CCC3)C(C4=C1[[email protected]](C)CO4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

IsocryptotanshinoneSTATPhosphataseInhibitorinhibitorinhibit

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