1. JAK/STAT Signaling
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. STAT
    Phosphatase

Isocryptotanshinone 

Cat. No.: HY-N6651
Handling Instructions

Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.

For research use only. We do not sell to patients.

Isocryptotanshinone Chemical Structure

Isocryptotanshinone Chemical Structure

CAS No. : 22550-15-8

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  • Biological Activity

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  • References

Description

Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.

IC50 & Target[1][2]

STAT3

 

PTP1B

56.1 μM (IC50)

In Vitro

It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3743 mL 16.8714 mL 33.7427 mL
5 mM 0.6749 mL 3.3743 mL 6.7485 mL
10 mM 0.3374 mL 1.6871 mL 3.3743 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

296.36

Formula

C₁₉H₂₀O₃

CAS No.

22550-15-8

SMILES

O=C1C2=C(C3=C(C=C2)C(C)(C)CCC3)C(C4=C1[[email protected]](C)CO4)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Isocryptotanshinone
Cat. No.:
HY-N6651
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Isocryptotanshinone

Cat. No.: HY-N6651