22550-15-8
Chemical Structure
Isocryptotanshinone
- CAS No.: 22550-15-8
- Formula:C19H20O3
- Molecular Weight:296.36
IUPAC Name: (S)-4,4,8-trimethyl-1,2,3,4,8,9-hexahydrophenanthro[3,2-b]furan-7,11-dione
InChIKey: VUIHARLRBGHPEA-SNVBAGLBSA-N
SMILES: O=C1C2=C(C3=C(C=C2)C(C)(C)CCC3)C(C4=C1[C@H](C)CO4)=O
Biological Activity: Isocryptotanshinone is a dual STAT3 and PTP1B (IC50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation[1][2]. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC[1][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isocryptotanshinone | 98% | Isocryptotanshinone is a dual STAT3 and PTP1B (IC50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC. | ||||||||||||||||||||
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- [1]. Guo S, et al. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Dec;24(10):934-942. [Content Brief]
- [3]. Zhang X, et al. Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. J Breast Cancer. 2015 Jun;18(2):112-8. [Content Brief]
- [4]. Chen ZM, et al. Inhibitory effects of isocryptotanshinone on gastric cancer. Sci Rep. 2018 Jun 18;8(1):9307. [Content Brief]
Keywords
