1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. STAT3-IN-3

STAT3-IN-3 

Cat. No.: HY-128588 Purity: 98.08%
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STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research.

For research use only. We do not sell to patients.

STAT3-IN-3 Chemical Structure

STAT3-IN-3 Chemical Structure

CAS No. : 2361304-26-7

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
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100 mg USD 3500 In-stock
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Description

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research[1].

IC50 & Target[1]

STAT3

 

In Vitro

STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2[1].
STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1[1].
STAT3-IN-3 increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway[1].
STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7cells with IC50s of 1.43, 1.89, 2.88, and 3.33 μM, respectively[1].
STAT3-IN-3 exhibits selective inhibitory activity against cancer cells (IC50=14.62 μM for MCF-10A cells and IC50=35.60 μM for human normal cells, L02 cells)[1].
STAT3-IN-3 markedly inhibits the proliferation of MDA-MB-231cells and there was almost a cessation of colony formation at 2 μM[1].
STAT3-IN-3 (1-4 μM ;24 hours) induces apoptosis in cancer cells via the mitochondrial pathway[1].
STAT3-IN-3 (1-4 μM ;24 hours) can induce the cleavage of Caspase-9, Caspase-3 and PARP[1].
STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation[1].
STAT3-IN-3 inhibits STAT3 DNA-binding activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells
Concentration: MTT assay
Incubation Time: 48 hours
Result: Exhibited anti-proliferative activity.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates.

Western Blot Analysis[1]

Cell Line: MDA-MB-231cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Induced the cleavage of Caspase-9, Caspase-3 and PARP.
In Vivo

STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily, for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female BALB/c mice (6 weeks of age)[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Intraperitoneal injection, daily, for 14 days
Result: Significantly inhibited tumor volume.
Molecular Weight

600.48

Formula

C₂₇H₂₆BrN₃O₆S

CAS No.

2361304-26-7

SMILES

BrC1=C2C(S(C(C(N3CCN(C(C4=CC5=CC=C(N(CC)CC)C=C5OC4=O)=O)CC3)=O)=C2)(=O)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6653 mL 8.3267 mL 16.6533 mL
5 mM 0.3331 mL 1.6653 mL 3.3307 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

STAT3-IN-3STATSTAT3mitochondria-targetingantitumormitochondrialapoptosispathwayInhibitorinhibitorinhibit

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