2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Akt mTOR JAK STAT Apoptosis Caspase Reactive Oxygen Species (ROS) NO Synthase
  4. PI3K/Akt/mTOR-IN-7

PI3K/Akt/mTOR-IN-7 is an AKT/mTOR and JAK2/STAT3 inhibitor. PI3K/Akt/mTOR-IN-7 restores p-Akt, p-mTOR, and p-STAT3 expression, reduces pro-apoptotic Caspase-3 mRNA expression. PI3K/Akt/mTOR-IN-7 reduces intracellular ROS accumulation and inhibits NO production. PI3K/Akt/mTOR-IN-7 can be used for research on stroke, Alzheimer's disease and Parkinson's disease.

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PI3K/Akt/mTOR-IN-7

PI3K/Akt/mTOR-IN-7 Chemical Structure

CAS No. : 2925588-01-6

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PI3K/Akt/mTOR-IN-7 Related Antibodies

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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nNOS iNOS eNOS

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Description

PI3K/Akt/mTOR-IN-7 is an AKT/mTOR and JAK2/STAT3 inhibitor. PI3K/Akt/mTOR-IN-7 restores p-Akt, p-mTOR, and p-STAT3 expression, reduces pro-apoptotic Caspase-3 mRNA expression. PI3K/Akt/mTOR-IN-7 reduces intracellular ROS accumulation and inhibits NO production. PI3K/Akt/mTOR-IN-7 can be used for research on stroke, Alzheimer's disease and Parkinson's disease[1].

IC50 & Target[1]

JAK2

 

STAT3

 

Caspase-3

 

In Vitro

PI3K/Akt/mTOR-IN-7 (DG23) (10 μM; 24 h) shows no significant cytotoxicity toward BV2 microglial cells at 10 μM[1].
PI3K/Akt/mTOR-IN-7 (10 μM; 24 h) inhibits nitric oxide production in LPS (HY-D1056)-stimulated BV2 microglial cells by 51.62% at 10 μM[1].
PI3K/Akt/mTOR-IN-7 (10 μM; 24 h) shows no obvious cytotoxicity toward SH-SY5Y human neuroblastoma cells at 10 μM[1].
PI3K/Akt/mTOR-IN-7 (10 μM; 26 h) confers neuroprotection against H2O2-induced oxidative damage in SH-SY5Y human neuroblastoma cells with a 42.68% cell viability rescue rate at 10 μM, and exhibits a concentration-dependent protective effect[1].
PI3K/Akt/mTOR-IN-7 (10 μM; 8 h) most potently inhibits H2O2-induced upregulation of pro-apoptotic Bcl-2/Bax and Caspase-3 mRNA expression in SH-SY5Y human neuroblastoma cells[1].
PI3K/Akt/mTOR-IN-7 (2.5-10 μM; 8 h) dose-dependently inhibits H2O2-induced reactive oxygen species accumulation in SH-SY5Y human neuroblastoma cells, with significant effects observed at 5 μM and 10 μM[1].
PI3K/Akt/mTOR-IN-7 (2.5-10 μM; 8 h) dose-dependently reduces H2O2-induced Caspase-3 protein expression and restores p-Akt, p-mTOR, and p-STAT3 protein expression in SH-SY5Y human neuroblastoma cells at 2.5-10 μM, with greater potency than diosgenin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/Akt/mTOR-IN-7 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: BV2 microglial cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Showed no significant cytotoxicity in BV2 cells.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Showed no obvious cytotoxicity in SH-SY5Y cells.

Real Time qPCR[1]

Cell Line: H2O2-injured SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: 26 h
Result: Significantly attenuated H2O2-induced upregulation of Bcl-2/Bax and Caspase-3 mRNA expression.
Reduced the Bcl-2/Bax ratio to 3.54 and Caspase-3 expression to 1.03.

Western Blot Analysis[1]

Cell Line: H2O2-injured SH-SY5Y human neuroblastoma cells
Concentration: 2.5 μM; 5 μM; 10 μM
Incubation Time: 8 h
Result: Dose-dependently decreased H2O2-induced Caspase-3 protein expression, with marked downregulation in the 10 μM group relative to the H2O2-only group.
Dose-dependently upregulated the p-Akt/Akt, p-mTOR/mTOR, and p-STAT3/STAT3 ratios, restoring phosphorylated protein expression to levels superior to diosgenin at equivalent concentrations.
Molecular Weight

605.76

Formula

C36H47NO7
CAS No.
SMILES

C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=C[C@@H]4OC(/C=C/C6=C(C=CC=C6)[N+]([O-])=O)=O)C)([H])CC2)([H])O[C@]7(CC[C@H](CO7)C)[C@H]3C
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Purity & Documentation
References
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PI3K/Akt/mTOR-IN-7 Related Classifications

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Keywords:

PI3K/Akt/mTOR-IN-72925588-01-6AktmTORJAKSTATApoptosisCaspaseReactive Oxygen Species (ROS)NO SynthasePKBProtein kinase BMammalian target of RapamycinJanus kinaseNitric oxide synthasesNOSAKT/mTOR signaling pathwaysCaspase-3JAK2/STAT3 signaling pathwaysSH-SY5Y human neuroblastoma cellsreactive oxygen speciesnitric oxideSTAT3BV2 microglial cellsInhibitorinhibitorinhibit

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