PROTAC c-Met degrader-5
PROTAC c-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader with DC50s of 0.42 and 0.32 nM in EBC-1 and Hs746T cells, respectively. PROTAC c-Met degrader-5 significantly induces cell apoptosis, G1 cell cycle arrest, and inhibits cell migration and invasion. PROTAC c-Met degrader-5 has potent antiproliferative and degradation efficacy against c-Met-addicted cancer cells and Tepotinib (HY-14721)-resistant cancer cells. Pink: c-Met ligand (HY-W425461); Blue: CRBN ligase ligand (HY-14658); Black: linker
(Pink: c-Met/HGFR ligand (HY-W425461); Blue: Cereblon ligand (HY-14658); Black: linker).
For research use only. We do not sell to patients.
- Formula: C47H46N10O6
- Molecular Weight:846.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
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Biological Activity
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p-STAT3 |
Chemical Information
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Molecular Weight 846.93
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Formula C47H46N10O6
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SMILES
O=C1C=CC(C2=CC(C#N)=CC=C2)=NN1CC3=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CCN6CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9C(NC(CC9)=O)=O)=O)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC c-Met degrader-5 Related Classifications
HY-175320 Related Classifications
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