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Cat. No.: HY-N21550

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(-)-Salcolin B

Name: (-)-Salcolin B
Brand: MedChemExpress
SKU: HY-N21550
Availability: PreOrder

(Synonyms: Tricin 4'-O-(threo-β-guaiacylglyceryl)ether)

(-)-Salcolin B (Tricin 4'-O-(threo-β-guaiacylglyceryl) ether) is an isomer of Salcolin B (HY-N16766) and anti-inflammatory agent. (-)-Salcolin B is isolable from Njavara. (-)-Salcolin B downregulates the activities of NF-κB and STAT3, reduces the expressions of iNOS and COX-2, activates the ERK signaling pathway, and inhibits LPS-induced NO and ROS production. (-)-Salcolin B induces Apoptosis. (-)-Salcolin B inhibits TPA (HY-18739)-induced ear edema. (-)-Salcolin B possesses antioxidant activity. (-)-Salcolin B can be used in research related to inflammatory diseases, colon adenocarcinoma, ovarian cancer and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1292294-32-6
Formula: C₂₇H₂₆O₁₁
Molecular Weight:526.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Salcolin B Chemical Structure

CAS No.: 1292294-32-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

COX-2

STAT3

iNOS

All NF-κB Isoforms :

All STAT Isoforms :

All NO Synthase Isoforms :

All COX Isoforms :

All ERK Isoforms :

In Vitro

Tricin 4'-O-(threo-β-guaiacylglyceryl) ether (10-40 μg/mL; 15 min) dose-dependently inhibits LPS-induced ROS generation in RAW264.7 cells^[1].
Tricin 4'-O-(threo-β-guaiacylglyceryl) ether (10-40 μg/mL; 24 h) dose-dependently inhibits LPS-induced NO generation in RAW264.7 cells^[1].
Tricin 4'-O-(threo-β-guaiacylglyceryl) ether (10-40 μg/mL; 8 h) dose-dependently inhibits LPS-induced iNOS transcriptional activity in RAW264.7 cells^[1].
Tricin 4'-O-(threo-β-guaiacylglyceryl) ether (10-40 μg/mL; 24 h) dose-dependently inhibits LPS-induced PGE₂ generation in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

mouse macrophage-like RAW264.7 cells
Concentration:

10-40 μg/mL
Incubation Time:

24 h
Result:

Significantly reduced LPS-induced PGE₂ production in a dose-dependent manner, with each tested concentration producing a statistically significant decrease compared to LPS-only treated cells.

In Vivo

Tricin 4'-O-(threo-β-guaiacylglyceryl)ether (0.1-0.5 mg/ear; topical; single dose) exhibits dose-dependent anti-inflammatory activity in TPA (HY-18739)-induced mouse ear edema, with the 0.5 mg/ear dose reducing ear thickness by ~44% and ear punch weight by ~56% via down-regulation of NF-κB and STAT3 signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male)^[1]
Dosage:

0.1 mg/ear; 0.5 mg/ear
Administration:

topical; single dose
Result:

Suppressed TPA-induced iNOS and COX-2 protein expression in ear tissue, inhibited NF-κB DNA-binding activity, blocked phosphorylation of IKKα/β and IκB, reduced nuclear translocation of p50 and p65, and inhibited STAT3 phosphorylation at both doses.
Reduced cell infiltration and decreased staining for F4/80, CD3, and COX-2 in ear tissue treated with 0.5 mg/ear.

Chemical Information

CAS No. 1292294-32-6
Molecular Weight 526.49
Formula C₂₇H₂₆O₁₁
SMILES

O=C1C=2C(OC(=C1)C3=CC(OC)=C(O[C@H]([C@H](O)C4=CC(OC)=C(O)C=C4)CO)C(OC)=C3)=CC(O)=CC2O
Synonyms

Tricin 4'-O-(threo-β-guaiacylglyceryl)ether
Structure Classification
- Flavonoids
- Flavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jung YS, et al. Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema. Toxicology and applied pharmacology. 2014 May 15;277(1):67-76.

[2]. Ajitha MJ, et al. DPPH radical scavenging activity of tricin and its conjugates isolated from "Njavara" rice bran: a density functional theory study. Journal of agricultural and food chemistry. 2012 Apr 11;60(14):3693-9.

[3]. Mohanlal S, et al. Tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether isolated from Njavara (Oryza sativa L. var. Njavara), induce apoptosis in multiple tumor cells by mitochondrial pathway. J Nat Med. 2013 Jul;67(3):528-33.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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(-)-Salcolin B

All NF-κB Isoforms

All STAT Isoforms

All NO Synthase Isoforms

All COX Isoforms

All ERK Isoforms