1292294-32-6
Chemical Structure
(-)-Salcolin B
Synonym(s): Tricin 4'-O-(threo-β-guaiacylglyceryl)ether
- CAS No.: 1292294-32-6
- Formula:C27H26O11
- Molecular Weight:526.49
IUPAC Name: 2-(4-(((1R,2S)-1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl)oxy)-3,5-dimethoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
InChIKey: WXNJNHFYIWEHIL-AZGAKELHSA-N
SMILES: O=C1C=2C(OC(=C1)C3=CC(OC)=C(O[C@H]([C@H](O)C4=CC(OC)=C(O)C=C4)CO)C(OC)=C3)=CC(O)=CC2O
Biological Activity: (-)-Salcolin B (Tricin 4'-O-(threo-β-guaiacylglyceryl) ether) is an isomer of Salcolin B (HY-N16766) and anti-inflammatory agent. (-)-Salcolin B is isolable from Njavara. (-)-Salcolin B downregulates the activities of NF-κB and STAT3, reduces the expressions of iNOS and COX-2, activates the ERK signaling pathway, and inhibits LPS-induced NO and ROS production. (-)-Salcolin B induces Apoptosis. (-)-Salcolin B inhibits TPA (HY-18739)-induced ear edema. (-)-Salcolin B possesses antioxidant activity. (-)-Salcolin B can be used in research related to inflammatory diseases, colon adenocarcinoma, ovarian cancer and breast cancer[1][2][3].
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(-)-Salcolin B | (-)-Salcolin B (Tricin 4'-O-(threo-β-guaiacylglyceryl) ether) is an isomer of Salcolin B (HY-N16766) and anti-inflammatory agent. (-)-Salcolin B is isolable from Njavara. (-)-Salcolin B downregulates the activities of NF-κB and STAT3, reduces the expressions of iNOS and COX-2, activates the ERK signaling pathway, and inhibits LPS-induced NO and ROS production. (-)-Salcolin B induces Apoptosis. (-)-Salcolin B inhibits TPA (HY-18739)-induced ear edema. (-)-Salcolin B possesses antioxidant activity. (-)-Salcolin B can be used in research related to inflammatory diseases, colon adenocarcinoma, ovarian cancer and breast cancer. | |||||||||||||||||||||
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- [1]. Jung YS, et al. Anti-inflammatory effect of tricin 4'-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema. Toxicology and applied pharmacology. 2014 May 15;277(1):67-76.
- [2]. Ajitha MJ, et al. DPPH radical scavenging activity of tricin and its conjugates isolated from "Njavara" rice bran: a density functional theory study. Journal of agricultural and food chemistry. 2012 Apr 11;60(14):3693-9.
- [3]. Mohanlal S, et al. Tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether isolated from Njavara (Oryza sativa L. var. Njavara), induce apoptosis in multiple tumor cells by mitochondrial pathway. J Nat Med. 2013 Jul;67(3):528-33.
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