2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STX-0119

STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.

For research use only. We do not sell to patients.

STX-0119 Chemical Structure

STX-0119 Chemical Structure

CAS No. : 851095-32-4

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Based on 1 publication(s) in Google Scholar

STX-0119 Related Antibodies

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Description

STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1].

IC50 & Target[1]

STAT3

74 μM (IC50, STAT3 transcription)

In Vitro

STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells[1].
STX-0119 (10-50 μM; 24 h) reduces the expression of STAT3 target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STX-0119 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 10, 20 and 50 μM
Incubation Time: 24 h
Result: Reduced the expression of STAT3 target proteins, namely, c-myc, cyclin D1, and survivin, in a concentration-dependent manner. Did not suppress the expression of those STAT3-regulated oncoproteins.
In Vivo

STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice[1].
The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/cA-ν/ν nude mice, SCC-3 lymphoma xenograft model[1]
Dosage: 160 mg/kg
Administration: Oral gavage, daily for 4 days
Result: Suppressed the growth of SCC-3 cells significantly on the fourth day.
Molecular Weight

382.37

Formula

C22H14N4O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC(C2=CC=CC=C2)=NC3=C1C=CC=C3)NC4=NN=C(C5=CC=CO5)O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 13.33 mg/mL (34.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6153 mL 13.0763 mL 26.1527 mL
5 mM 0.5231 mL 2.6153 mL 5.2305 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6153 mL 13.0763 mL 26.1527 mL 65.3817 mL
5 mM 0.5231 mL 2.6153 mL 5.2305 mL 13.0763 mL
10 mM 0.2615 mL 1.3076 mL 2.6153 mL 6.5382 mL
15 mM 0.1744 mL 0.8718 mL 1.7435 mL 4.3588 mL
20 mM 0.1308 mL 0.6538 mL 1.3076 mL 3.2691 mL
25 mM 0.1046 mL 0.5231 mL 1.0461 mL 2.6153 mL
30 mM 0.0872 mL 0.4359 mL 0.8718 mL 2.1794 mL
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STX-0119 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STX-0119851095-32-4STX0119STX 0119STATorally activeSTAT3 dimerizationHEK293MDA-MB-468SCC-3Inhibitorinhibitorinhibit

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